Toddaline
6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2H-chromen-2-one
CAS: 483-90-9
Molecular Formula: C16H20O6
Toddaline - Names and Identifiers
Toddaline - Physico-chemical Properties
| Molecular Formula | C16H20O6 |
| Molar Mass | 308.33 |
| Density | 1.269±0.06 g/cm3(Predicted) |
| Melting Point | 269-270°C |
| Boling Point | 530.0±50.0 °C(Predicted) |
| Specific Rotation(α) | (CHCl3)+55.9 |
| Flash Point | 195.5°C |
| Solubility | Soluble in chloroform, methanol |
| Vapor Presure | 4.61E-12mmHg at 25°C |
| Appearance | White powder or crystal |
| pKa | 14.39±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.568 |
| MDL | MFCD11042251 |
| Physical and Chemical Properties | Light yellow crystalline powder, soluble in methanol, derived from Zanthoxylum nitidum, Feilong palm blood. |
| In vitro study | Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1. |
Toddaline - Reference Information
| overview | feilongzhang blood lactone, also known as nitidum, is a coumarin compound with a molecular formula of C16H20O6 and a molecular weight of 308.33. Zanthoxylum nitidum exists in Rutaceae (Rutaceae), Zanthoxylum bungeanum (Roxb.), Zanthoxylumnitidum(Roxb.)DC.), Zanthoxylum bungeanum (Zanthoxylumnitidumvar.fastuosum), and Toddaliaasiatica(L.)Lam.[PaulliniaasiaticaL.]). |
| biological activity | Toddalolactone,Toddalia the main component of asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor -1 (PAI-1), IC50 is 37.31 μM. |
| target | TargetValue PAI-1 () 37.31 μM |
| Target | Value |
| PAI-1 () | 37.31 μM |
| in vitro study | Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1. |
| chemical properties | light yellow crystalline powder, soluble in methanol, derived from Zanthoxylum nitidum, dragon palm blood. |
| use | nitidum has anti-inflammatory, analgesic, anti-cancer and antispasmodic effects. used for content determination/identification/pharmacological experiment, etc. |
Last Update：2024-04-09 21:11:58
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