Terfenadine
Terfenadine
CAS: 50679-08-8
Molecular Formula: C32H41NO2
Terfenadine - Names and Identifiers
Terfenadine - Physico-chemical Properties
| Molecular Formula | C32H41NO2 |
| Molar Mass | 471.67 |
| Density | 1.0488 (rough estimate) |
| Melting Point | 145-152 °C |
| Boling Point | 572.76°C (rough estimate) |
| Water Solubility | 0.001 g/100 mL (30 ºC) |
| Solubility | 0.001 g/100 mL (30 °C) |
| Appearance | morphology neat |
| pKa | pKa 9.21(H2O t = 25 I = 0.025) (Uncertain) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6310 (estimate) |
| MDL | MFCD00079622 |
| Physical and Chemical Properties | Chemical properties crystallize from acetone, melting point 146.5~148.5 ℃; There are three crystal forms: melting point 149~152 ℃, melting point 146-148 ℃, melting point 142~144 ℃. Solubility at 30 ℃ (g/100ml): water 0.001, ethanol 3.780, methanol 3.750, hexane 0.034,0.1mol/L 0.012 hydrochloride, 0.1mol.L citric acid 0.110,0.1mol/L tartaric acid 0.045. UV maximum absorption (methanol):260nm(A 660.4);(ethanol):260nm(A 671.4);(dichloromethane):260nm(A 762.2). Acute toxicity LD50 rats, mice, guinea pigs (mg/kg): all> 2000 oral. |
| Use | Use of novel antihistamines, with specific peripheral H1 receptor antagonism, and no anti-serotonin, anti-cholinergic and anti-adrenergic effects. Suitable for seasonal allergic rhinitis (hay fever), perennial allergic rhinitis, acute and chronic urticaria treatment. |
Terfenadine - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | TM4969000 |
| HS Code | 29333999 |
| Toxicity | LD50 orally in mice: >2000 mg/kg (Carr, Meyer) |
Terfenadine - Upstream Downstream Industry
Terfenadine - Reference
| Reference Show more | 1. Yixuan Cui, Di Liu, Mengqiang Zhao, Junmei Li, Yuke Yang, Mengjiao Li, Jinglin Gao, Ye Jiang, A fast and simple approach for the quantification of five anti-hypersensitivity drugs in saliva and urine by portable ion mobility spectrometry based on magnetic 2. [IF=3.935] Yixuan Cui et al."A fast and simple approach for the quantification of five anti-hypersensitivity drugs in saliva and urine by portable ion mobility spectrometry based on magnetic graphene oxide dispersive solid phase extraction."J Pharmaceut Biomed. 2020 |
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View History
Terfenadine
ACETOPHENONE FOR SYNTHESIS 25 L
354813-19-7
水质稳定剂EDTMPS
colistin sulfate
202920-22-7
1019502-17-0
60623-67-8
13588-95-9
ACETOPHENONE FOR SYNTHESIS 25 L
354813-19-7
水质稳定剂EDTMPS
colistin sulfate
202920-22-7
1019502-17-0
60623-67-8
13588-95-9
Raw Materials for Terfenadine
Toluene
Potassium hydroxide
Acetone
Sodium borohydride
Potassium iodide
Isobutylbenzene
4-Piperidinemethanol
4-Chlorobutyryl chloride
Potassium hydroxide
Acetone
Sodium borohydride
Potassium iodide
Isobutylbenzene
4-Piperidinemethanol
4-Chlorobutyryl chloride