Tabe
pirenzepine dihydrochloride
CAS: 29868-97-1
Molecular Formula: C19H23Cl2N5O2
Tabe - Names and Identifiers
| Name | pirenzepine dihydrochloride |
| Synonyms | Tabe Leblon Maghen Ulcosan Renzepin Gasteril Ulcuforton Pirenzepine HCL PIRENZEPINE HCL HYDRATE pirenzepine hydrochloride pirenzepine dihydrochloride 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrate hydrochloride 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride 5,11-Dihydro-11-((4-methylpiperazin-1-yl)acetyl)-6H-pyrido(2,3-b)-(1,4)benzodiazepin-6-one dihydrochloride 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-β][1,4]benzo- diazepin-6-one Dihydrochloride |
| CAS | 29868-97-1 |
| EINECS | 249-907-5 |
| InChI | InChI=1/C19H21N5O2.ClH.H2O/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);1H;1H2 |
Tabe - Physico-chemical Properties
| Molecular Formula | C19H23Cl2N5O2 |
| Molar Mass | 424.32 |
| Melting Point | 248-250°C |
| Solubility | H2O: 50mg/mL |
| Appearance | powder |
| Color | white |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | Hygroscopic |
| MDL | MFCD00055214 |
| Use | For the treatment of gastric and duodenal ulcer, acute gastric mucosal bleeding and other diseases |
| In vitro study | The antisecretory properties of pirenzepine on gastric acid and pepsin secretion may be attributed to the antagonistic activity of the drug on muscarinic M1 receptors of gastric intramural plexuses, whereas the effect on parietal muscarinic M2 receptors seems of less importance. Additional inhibitory mechanisms on gastric secretion may be represented by pirenzepine-induced increase in somatostatin release from gastrointestinal system. Significant cytoprotective properties of pirenzepinehave been observed on a variety of experimentally induced peptic ulcerations. Pirenzepine (5-500 μg/mL) inhibits agonist-(acetylcholine-, carbachol- or nicotine-) induced contractions of the toad isolated rectus abdominis muscle, and depresses electrically provoked twitches of the rat phrenic nerve-hemidiaphragm muscle preparation. |
| In vivo study | Pirenzepine is potent in impairing learning of an avoidance; much higher doses are required to antagonize other central muscarinic effects. Pirenzepine is found to impair passive avoidance learning when given i.c.v. 20 min pre-training. The median latencies in pirenzepine-treated animals are 79.5, 11, 27 and 25.5 seconds with doses of 0.03, 0.1, 0.3 and 1 μg per mouse respectively. Acid and pepsin secretion stimulated by either bethanechol or the vagus are inhibited in a dose-responsive manner by pirenzepine. Pirenzepine (5-25 mg/kg i.v.) depresses indirect electrical stimulation-evoked twitches of the cat tibialis anterior and soleus muscle preparations. |
Tabe - Risk and Safety
| WGK Germany | 2 |
| RTECS | UU7883000 |
Tabe - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.357 ml | 11.784 ml | 23.567 ml |
| 5 mM | 0.471 ml | 2.357 ml | 4.713 ml |
| 10 mM | 0.236 ml | 1.178 ml | 2.357 ml |
| 5 mM | 0.047 ml | 0.236 ml | 0.471 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Featured ProductsSpot supply
Product Name: 11-(2-(4-Methylpiperazin-1-yl)acetyl)-5,11-dihydro-6H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one dihydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Pirenzepine dihydrochloride Request for quotationCAS: 29868-97-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Pirenzepine hydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Pirenzepine hydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Pirenzepine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Pirenzepine dihydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: 11-(2-(4-Methylpiperazin-1-yl)acetyl)-5,11-dihydro-6H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one dihydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Pirenzepine dihydrochloride Request for quotationCAS: 29868-97-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Pirenzepine hydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Pirenzepine hydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Pirenzepine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Pirenzepine dihydrochloride Visit Supplier Webpage Request for quotationCAS: 29868-97-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History