TYLOXAPOL
Triton
CAS: 25301-02-4
Molecular Formula: C17H28O3
TYLOXAPOL - Names and Identifiers
| Name | Triton |
| Synonyms | Triton oxirane alevaire TYLOXAPOL macrocyclon 4-(1,1,3,3-tetramethylbutyl)phenol 4-(1,1,3,3-tetramethylbutyl)-phenopolymerwithformaldehydeandoxirane formaldehyde,polymerwithoxiraneand4-(1,1,3,3-tetramethylbutyl)phenol |
| CAS | 25301-02-4 |
| InChI | InChI=1/C14H22O.C2H4O.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;1-2-3-1;1-2/h6-9,15H,10H2,1-5H3;1-2H2;1H2 |
TYLOXAPOL - Physico-chemical Properties
| Molecular Formula | C17H28O3 |
| Molar Mass | 280.402 |
| Density | 1.1 |
| Boling Point | 282.3°C at 760 mmHg |
| Flash Point | 148.3°C |
| Vapor Presure | 0.00198mmHg at 25°C |
| Appearance | Morphological Viscous Liquid |
| Color | Clear to hazy yellow to amber |
| Merck | 13,9901 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Physical and Chemical Properties | Bioactive Tyloxapol (Triton WR1339) is a non-ionic liquid polymer of alkyl aryl polyether alcohols, which is used as a surfactant during liquefaction and removes mucopurulent and bronchial and pulmonary secretions. It also inhibits plasma lipolytic activity, which breaks down triacylglycerol-rich lipoproteins. |
TYLOXAPOL - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | SM9750000 |
| HS Code | 29222990 |
TYLOXAPOL - Upstream Downstream Industry
| Raw Materials | Formaldehyde ETHYLENE OXIDE |
| Downstream Products | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE |
TYLOXAPOL - Nature
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
Last Update：2024-04-10 22:29:15
TYLOXAPOL - Uses and synthesis methods
Target
Target Value
lipoprotein lipase
in vitro studies
Tyloxapol is considered a safe stabilizer. In some studies, Tyloxapol has been reported to have toxic effects in epithelial cells and red blood cells, inducing apoptosis in RAW264.7 mouse phages and NIH/3T3 cells, and inducing lysis in human Jurkat T lymphocytes. However, these toxic effects do not reflect the in vivo effects of Tyloxapol, and they are rarely used alone in clinical practice.
In vivo studies
In rats, a single injection of 400 mg/kg tyloxapol by intravenous injection will produce three different stages in plasma lipids: relative to the basal level, there will be a rapid linear increase, then a relatively gentle linear increase, and finally a slow decrease. The treatment of Tyloxapol enhanced the pulmonary absorption of insulin and the absorption of inhaled insulin in a diabetic rat model. In diabetic rat models, the drug may significantly enhance the hypoglycemic effect of insulin perfused through the trachea, but does not change LDH activity.
Last Update：2024-04-09 22:09:11
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Raw Materials for TYLOXAPOL
Downstream Products for TYLOXAPOL