TMS
TMS
CAS: 24144-92-1
Molecular Formula: C18H20O4
TMS - Names and Identifiers
TMS - Physico-chemical Properties
| Molecular Formula | C18H20O4 |
| Molar Mass | 300.35 |
| Density | 1.117±0.06 g/cm3(Predicted) |
| Melting Point | 78-79 °C |
| Boling Point | 459.9±40.0 °C(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | TMS, an analogue of resveratrol, is considered to be a potential cancer preventive agent since it is a potent inhibitor of CYP1B1. To assess survival of MCF-7 cells exposed to 1 μM benzo[a]pyrene (BP), 1 μM BP+1 μM TMS and 1 μM BP+4 μM TMS, cells ae incubated for up to 72 h without a media change. Luminescence units from exposed cells, expressed as a percentage of luminescence units from solvent (DMSO)-treated cells at the same time intervals. In all exposure groups, cell viability remains >90% for the first 24 h, but by 72 h, cell survival drops to 60-70%. |
| In vivo study | To determine the contribution of CYP1B1 in development of hypertension in spontaneously hypertensive rats (SHR), the effect of TMS is examined on in SHR and WKY rats. Systolic BP steadily increases in SHR from 4 weeks of age. Starting from 8 weeks of age, daily injections of TMS reduce systolic BP in SHR to levels observed at the beginning of the experiment (207±7 vs. 129±2 mmHg). Systolic BP is not altered in WKY injected with TMS or its vehicle (129±7 vs. 127±4 mmHg) . |
TMS - References
| biological activity | TMS ((E)-2,3 ',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki of 3 nM. The inhibitory effect of TMS on CYP1A1 (IC50=300 nM) and CYP1A2 (IC50=3.1 μm) was small. TMS is a methylated derivative of resveratrol, which has anti-cancer activity. |
Last Update：2024-04-09 21:11:58
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