TMBA
3,4,5-Trimethoxybenzaldehyde
CAS: 86-81-7
Molecular Formula: C10H12O4
TMBA - Names and Identifiers
| Name | 3,4,5-Trimethoxybenzaldehyde |
| Synonyms | TMBA NSC 16692 AI3-36673 BRN 0395163 OTAVA-BB BB7018801952 Trimetazidine Impurity 9 3,4,5-Trimethoxybenzaldeh 3,4,5-methoxybenzaldehyde 3,4,5-tiMethoxybenzaldehyde 3,4,5-Trimethoxybenzaldehyde 3,4,5-TriMethoxybenzaldenyde 3,4,5-TrimethoxybenZHldehyde BENZALDEHYDE,3,4,5-TRIMETHOXY- Benzaldehyde, 3,4,5-trimethoxy- Three, four, five - preparation benzaldehyde 4-08-00-02719 (Beilstein Handbook Reference) |
| CAS | 86-81-7 |
| EINECS | 201-701-6 |
| InChI | InChI=1/C10H12O4/c1-12-8-4-7(6-11)5-9(13-2)10(8)14-3/h4-6H,1-3H3 |
| InChIKey | OPHQOIGEOHXOGX-UHFFFAOYSA-N |
TMBA - Physico-chemical Properties
| Molecular Formula | C10H12O4 |
| Molar Mass | 196.2 |
| Density | 1.2166 (rough estimate) |
| Melting Point | 72-74 °C (lit.) |
| Boling Point | 163-165 °C/10 mmHg (lit.) |
| Flash Point | 163-165°C/10mm |
| Water Solubility | slightly soluble |
| Solubility | slightly soluble |
| Vapor Presure | 0.000565mmHg at 25°C |
| Appearance | White crystal |
| Color | White to creamy |
| BRN | 395163 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Air Sensitive |
| Refractive Index | 1.5550 (estimate) |
| MDL | MFCD00003364 |
| Physical and Chemical Properties | White to yellowish needle-like crystals. melting point 74-75 ℃ |
| Use | Trimethoprim for synthesis of antimicrobial Potentiator |
TMBA - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN2811 |
| WGK Germany | 3 |
| RTECS | CU8462000 |
| TSCA | Yes |
| HS Code | 29124900 |
| Hazard Note | Irritant |
TMBA - Reference
| Reference Show more | 1. Mireguli, niemeiming Yang, junmu, Bouli, ablizi, et al. Synthesis of 2 3 4-trimethoxychalcone derivatives and their anti-cervical cancer activity in vitro [J]. Journal of Xinjiang Medical University 2020 043(002):212-218. |
TMBA - Nature
Open Data Verified Data
white to yellowish needle-like crystals. Melting Point 74~75 °c.
Last Update：2024-01-02 23:10:35
TMBA - Preparation Method
Open Data Verified Data
with p-nitrotoluene as raw material, after oxidation-reduction, and then sodium nitrite diazotization, hydrolysis of p-hydroxybenzaldehyde, bromination, dimethoxylation, methylation and derived.
Last Update：2022-01-01 10:42:25
TMBA - Introduction
Slightly soluble in water, soluble in ethanol, toluene and acetone.
Last Update：2022-10-16 17:29:23
TMBA - Application
Open Data Verified Data
It is used as an important intermediate of sulfonamide synergist and antibacterial synergist TMP.
Last Update：2025-08-19 16:24:40
TMBA - Safety
Open Data Verified Data
- production equipment is required to be closed, and the workshop is well ventilated. Protective gear was worn by the operator.
- in a barrel. Store in a cool, dry, ventilated warehouse, tightly sealed. According to the general provisions of the storage and transportation of chemicals.
Last Update：2025-06-10 22:55:16
TMBA - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| trait | white to yellowish needle-like crystals. |
| Use | for synthesis of antibacterial synergist trimethoprim for synthesis of antibacterial synergist trimethoprim for use as sulfanilamide synergist, an important intermediate of the antibacterial synergist TMP. |
| production method | 1. From gallic acid (or tannic acid) by dimethyl sulfate methylation, esterification, and then hydrazine hydrate hydrazine reaction, and then the red blood salt oxidation system. The yield of industrial production was more than 70%. 2. From vanillin aldehyde by bromination, hydrolysis, methylation and derived. With p-nitrotoluene as raw material, by oxidation-reduction, then with sodium nitrite diazotization, hydrolysis of p-hydroxybenzaldehyde, bromination, dimethoxylation, methylation and derived. Further, 3,4, 5-trimethoxybenzaldehyde can also be prepared from trimethoxybenzonitrile and p-hydroxybenzaldehyde. |
Last Update：2024-04-09 02:00:12
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