SWF-86
Evacetrapib (LY2484595)
CAS: 1186486-62-3
Molecular Formula: C31H36F6N6O2
SWF-86 - Names and Identifiers
SWF-86 - Physico-chemical Properties
| Molecular Formula | C31H36F6N6O2 |
| Molar Mass | 638.65 |
| Density | 1.40 |
| Boling Point | 680.1±65.0 °C(Predicted) |
| pKa | 4.73±0.10(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Evacetrapib (LY2484595) inhibits human plasma CETP protein with an IC50 of 26 nM. There was no induction of aldosterone or cortisol synthesis by the action of Evacetrapib (LY2484595)(< 10 μm) on H295R cells. Evacetrapib (LY2484595) inhibits human plasma CETP protein with an IC50 of 26 nM. There was no induction of aldosterone or cortisol synthesis by the action of Evacetrapib (LY2484595)(< 10 μm) on H295R cells. |
| In vivo study | Human ApoAI and CETP double transgenic mice were orally treated with a dose of 30 mg/kg of Evacetrapib (LY2484595) and inhibited by 98.4%, 98.6%, respectively after 4 hours, 8 hours and 12 hours of treatment, and 18.4% CETP activity. After 8 hours of oral treatment with Evacetrapib (LY2484595)(30 mg/kg) resulted in an increase of 129.7% HDL-C. In a dose-response study, the ED50 values for inhibition of CETP activity were 3.5 mg/kg and 4.1 mg/kg, respectively, after 8 hours of oral treatment with Evacetrapib(LY2484595). Evacetrapib(LY2484595)(< 200 mg/kg) treatment of Zucker diabetic obese rats did not increase blood pressure. human ApoAI and CETP double transgenic mice were orally treated with a dose of 30 mg/kg of Evacetrapib (LY2484595) and inhibited by 98.4% after 4 hours, 8 hours, and 12 hours of treatment, respectively, 98.6%, and 18.4% CETP activity. After 8 hours of oral treatment with Evacetrapib (LY2484595)(30 mg/kg) resulted in an increase of 129.7% HDL-C. In a dose-response study, the ED50 values for inhibition of CETP activity were 3.5 mg/kg and 4.1 mg/kg, respectively, after 8 hours of oral treatment with Evacetrapib(LY2484595). Evacetrapib(LY2484595)(< 200 mg/kg) treatment of Zucker diabetic obese rats did not increase blood pressure. |
SWF-86 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.566 ml | 7.829 ml | 15.658 ml |
| 5 mM | 0.313 ml | 1.566 ml | 3.132 ml |
| 10 mM | 0.157 ml | 0.783 ml | 1.566 ml |
| 5 mM | 0.031 ml | 0.157 ml | 0.313 ml |
Last Update：2024-01-02 23:10:35
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