STENABOLIC
SR9009
CAS: 1379686-30-2
Molecular Formula: C20H24ClN3O4S
STENABOLIC - Names and Identifiers
STENABOLIC - Physico-chemical Properties
| Molecular Formula | C20H24ClN3O4S |
| Molar Mass | 437.94 |
| Density | 1.327±0.06 g/cm3(Predicted) |
| Boling Point | 547.2±45.0 °C(Predicted) |
| Physical and Chemical Properties | Acidity coefficient (pKa) 6.12±0.50(Predicted) |
STENABOLIC - Upstream Downstream Industry
STENABOLIC - Introduction
biological activity
Stenabolic (SR9009) is a synthetic REV-ERB agonist. The IC50 values for REV-ERB-α and REV-ERB-β are 670 nM and 800 nM, respectively.
target
Target Value
REV-ERB-α
(HEK293 cells) 670 nM
REV-ERB-β
(HEK293 cells) 800 nM
in vitro study
SR9009 has a lethal effect on cancer cells and aging cells induced by oncogenes (including melanocytic nevus), but has no effect on the vitality of normal cells and tissues. SR9009 regulates autophagy and lipid neogenesis, which plays a key role in inducing apoptosis in malignant cells. The treatment of cancer cells was treated with SR9009. By detecting caspase3 splicing and TUNEL test, the treatment of SR9009 cancer cells reduced their cell viability because apoptosis was induced. SR9009 reduces the number of autophagosomes, thus inhibiting autophagy.
in vivo studies
In food-borne obese mice, SR9909 can cause a decrease in fat mass and blood lipids. In vivo, SR9009 can inhibit the growth of malignant glioma and improve its survival rate in mice without causing obvious toxicity. SR9009 can penetrate the blood-brain barrier and inhibit tumor growth in a transplanted tumor model using malignant glioma migration from patients. In two different malignant glioma models, the survival rate is significantly improved.
Last Update：2024-04-09 20:52:54
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Featured Products
Product Name: SR 9009 Request for quotationCAS: 1379686-30-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Spot supply
Product Name: SR9009 Request for quotationCAS: 1379686-30-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: SR9009 Visit Supplier Webpage Request for quotationCAS: 1379686-30-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SR9009 Visit Supplier Webpage Request for quotationCAS: 1379686-30-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SR-9009 Visit Supplier Webpage Request for quotationCAS: 1379686-30-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
View History
Raw Materials for STENABOLIC
1-Pyrrolidinecarboxylic acid, 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-, 1,1-dimethylethyl ester
N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine
5-NITROTHIOPHENE-2-CARBOXALDEHYDE
Ethyl chloroformate
4-Chlorobenzylamine
N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine
5-NITROTHIOPHENE-2-CARBOXALDEHYDE
Ethyl chloroformate
4-Chlorobenzylamine