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S-ADENOSYL-L-METHIONINE

S-Adenosyl-L-Methionine Disulfate Tosylate

CAS: 29908-03-0

Molecular Formula: C15H22N6O5S

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S-ADENOSYL-L-METHIONINE - Names and Identifiers

Name S-Adenosyl-L-Methionine Disulfate Tosylate
Synonyms SAM-E
ADEMETIONINE
adenosylmethionine
methioninyladenylate
S-Adenosyl-L-methionine
p-Toluenesulfonate salt
S-ADENOSYL-L-METHIONINE
S-(5-Adenosyl)-L-methionine
S-(5'-Adenosyl)-L-methionine
ADEMETHIOINEDISULFATETOSYLATE
S-Adenosyl-L-Methionine Disulfate Tosylate
5-Deoxyadenosine-5-L-methionine disulfate ditosylate
adenosine,5'-((l-3-amino-3-carboxypropyl)methylsulfonio)-5'-deoxy-,hydroxide,
(3-amino-3-carboxypropyl){[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium (non-preferred name)
2-amino-4-[{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)sulfonio]butanoate (non-preferred name)
(3-amino-3-carboxypropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium (non-preferred name)
(2S)-2-amino-4-[{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)sulfonio]butanoate (non-preferred name)
[(3S)-3-amino-3-carboxypropyl]{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium (non-preferred name)
CAS 29908-03-0
EINECS 249-946-8
InChI InChI=1/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7?,8-,10-,11-,14-,27?/m1/s1

S-ADENOSYL-L-METHIONINE - Physico-chemical Properties

Molecular FormulaC15H22N6O5S
Molar Mass398.44
Storage ConditionInert atmosphere,Store in freezer, under -20°C
Physical and Chemical PropertiesThis product is the active type of methionine in the body.

S-ADENOSYL-L-METHIONINE - Risk and Safety

Risk CodesR49 - May cause cancer by inhalation
R23 - Toxic by inhalation
R34 - Causes burns
Safety DescriptionS53 - Avoid exposure - obtain special instructions before use.
S23 - Do not breathe vapour.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
HS Code29349990

S-ADENOSYL-L-METHIONINE - Reference Information

introduction adenosylmethionine, the main component of adenosylmethionine succinate, is a physiologically active molecule that exists in all tissues and body fluids of the human body. It participates in biochemical reactions in vivo as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione and coenzyme A, etc.). In the liver, the fluidity of the liver cell membrane is regulated by methylating the plasma membrane phospholipid, and the synthesis of sulfide products in the detoxification process can be promoted through the transsulfur reaction, and the alanine aminotransferase and aspartate aminotransferase can be reduced The amount of enzyme and bilirubin achieves the purpose of protecting liver function.
pharmacological effects adenosylmethionine is a physiologically active molecule that exists in all tissues and body fluids of the human body. It participates in important biochemical reactions in vivo as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione and coenzyme A). In the liver, the fluidity of the liver cell membrane is regulated by methylating the plasma membrane phospholipid, and the synthesis of sulfide products in the detoxification process can be promoted through the transsulfur reaction. As long as the bioavailability of adenosylmethionine in the liver is within the normal range, these reactions help prevent intrahepatic cholestasis.
physiological function S-adenosine-L-methionine (SAM) and glutathione (GSH) are two important bioactive molecules in organisms. SAM, also known as adenosylmethionine, is the active form of methionine, which is widely found in animals and plants. It is composed of substrates L-methionine and adenosine triphosphate (ATP) via S-adenosylmethionine synthetase (EC2.5.1.6) Enzymatic synthesis.
SAM is closely related to many metabolic processes in the human body. It is a biochemical drug that improves cell metabolism. It can increase the levels of GSH, sulfate and taurine in the liver through transthione, prevent hepatitis, fatty liver, liver fibrosis, liver cirrhosis and liver cancer, and also prevent liver damage caused by alcohol, drugs and cytokines.
Biological activity S-adenosylmethionine, also known as S-adenosylmethionine (Sadenosyl-L-methionine,SAM), is an important physiologically active substance widely existing in plants, animals and microorganisms. It has the functions of transmethyl, transsulfur and transaminopropyl, and participates in more than 40 biochemical reactions in the body, it is closely related to the biosynthesis of proteins, nucleic acids, neurotransmitters, phospholipids and vitamins. In addition, it also participates in the biotransformation of polyamines and glutathione. Studies have shown that S-adenosylmethionine is a compound produced by methionine and adenosine triphosphate (ATP) under the action of adenosylmethionine enzyme. It is a physiologically active substance that exists in all tissues and body fluids of the human body. As a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione and coenzyme A), it participates in important biochemical reactions in the body.
medical/health care effect S-adenosine-L-methionine (SAM) also has good therapeutic effect on arthritis, fibrous muscle, migraine and other diseases, and has little side effect. As early as the 1970s, SAM was used as a prescription drug for arthritis in Europe. In 1999, the US FDA approved SAM as a health product and has become one of the best-selling nutrition products in the United States.
preparation S-adenosylmethionine is mainly prepared by chemical synthesis, fermentation and enzymatic transformation. The fermentation method is to add the precursor L-methionine to the basic medium containing C and N sources, and a large amount of S-adenosylmethionine can be obtained by culturing microbial cells. This is currently the main route for industrial production of S-adenosylmethionine. Among them, the microorganisms used for fermentation can be obtained by screening or recombination construction methods, which are recorded in many articles and patents at home and abroad. Some studies have provided a preparation method of S-adenosylmethionine, using polyhydroxy organic reagents to protect the activity of the enzyme, using adenosine triphosphate precursor, L-methionine and phosphate ions as substrates, glucose or/and maltose as energy donors, adding a composition of metal ions, and using a permeable production strain to catalyze the production of S-adenosylmethionine in whole cells. Using the composition of metal ions to regulate the metabolic flow to improve the energy self-coupling efficiency, adding organic reagents to protect the activity of the bacteria and enzymes, using a permeable production strain to prepare S-adenosylmethionine, shorten the synthesis time, and make the product accumulate outside the cell, which can save the cost of subsequent separation and simplify the operation steps.
use clinically used to improve liver function. The combination with L-dopa for the treatment of Parkinson's disease can improve the efficacy of L-dopa and reduce side effects. Local pain, temporary anxiety and insomnia at the injection site can be seen.
Last Update：2024-04-09 20:45:29
S-ADENOSYL-L-METHIONINE
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Shanghai Amole Biotechnology Co., Ltd.
Multiple SpecificationsSpot supply
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CAS: 29908-03-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
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Product Name: Ademetionine Visit Supplier Webpage Request for quotation
CAS: 29908-03-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
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CAS: 29908-03-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
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SKYRUN INDUSTRIAL CO.,LTD
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Product Name: S-adenosyl-L-methionine Visit Supplier Webpage Request for quotation
CAS: 29908-03-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: S-Adenosyl-L-Methionine Disulfate Tosylate Request for quotation
CAS: 29908-03-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
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