Riodoxol
2,4,6-Triiodoresorcinol
CAS: 19403-92-0
Molecular Formula: C6H3I3O2
Riodoxol - Names and Identifiers
Riodoxol - Physico-chemical Properties
| Molecular Formula | C6H3I3O2 |
| Molar Mass | 487.8 |
| Density | 3.198±0.06 g/cm3(Predicted) |
| Melting Point | 144 °C |
| Boling Point | 267.3±40.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Brown |
| pKa | 5.96±0.28(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Physical and Chemical Properties | The chemical properties are fine needle-like crystals from carbon tetrachloride with a melting point of 155~157 ℃. |
| Use | The use is broad-spectrum, external antiviral drugs. It has good therapeutic effect on skin virus infection, skin fungal infection, papules, pustules and abscess acne. |
Riodoxol - Risk and Safety
| Hazard Class | IRRITANT |
Riodoxol - Upstream Downstream Industry
| Raw Materials | Potassium iodide |
Riodoxol - Uses and synthesis methods
overview
The earliest iodophenols were successfully developed by the former Soviet Union Chemical Medicine Research Center in the 2070s. At that time, hydrochloric acid was used as the catalyst, and iodine chloride (ICI) was used as the iodizing agent to directly react with m-diphenol on the aromatic ring. The reaction has the characteristics of mild reaction conditions and rapid reaction. However, because ICI is unstable, easy to decompose, expensive and toxic, it is not suitable for preparing iodophenols in the laboratory.
Introduction
iodophenols are 2,4, 6-triiodoresorcinol (2,4,6-Triiodoresorcine), which are white fine needle-like crystals. They were first produced by the Chemical Medicine Research Center of the former Soviet Union. Later, they aroused the interest of researchers in many other countries and produced a lot of research work.
Preparation
in a three-neck bottle, add 8.0g of sodium bicarbonate and 3.0g of resorcinol, add 150mL of water to dissolve, stir and drop the aqueous solution of iodine and potassium iodide, and control the temperature of the water at 9~11 ℃. After dropping, rest for 1h, filter, wash the filter cake with water, dry the filter cake at 50 ℃, recrystallize with carbon tetrachloride, decolorize with activated carbon to obtain white needle crystal, and obtain 9.4g of crystal after drying, with a yield of 70%.
Production method
Sodium bicarbonate and hydroquinone are dissolved in water, and the aqueous solution of iodine and potassium iodide is added dropwise under stirring, and the temperature is controlled at about 10±1 ℃. Let stand, filter solids, wash with water and dry. Recrystallization with carbon tetrachloride, decolorization and drying of activated carbon to obtain white needle-like crystalline iodophenol with 70% yield and melting point of 155.5-157 ℃.
Last Update：2024-04-09 21:01:54
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View History
Riodoxol
Bromooctyl magnesium
792-01-0
Grazoprevir Intermediate 5
巴拉酮
18245-94-8
40834-42-2
5731-01-1
1204246-72-9
104682-97-5
Bromooctyl magnesium
792-01-0
Grazoprevir Intermediate 5
巴拉酮
18245-94-8
40834-42-2
5731-01-1
1204246-72-9
104682-97-5
Raw Materials for Riodoxol