ROCILETINIB
CO-1686
CAS: 1374640-70-6
Molecular Formula: C27H28F3N7O3
ROCILETINIB - Names and Identifiers
ROCILETINIB - Physico-chemical Properties
| Molecular Formula | C27H28F3N7O3 |
| Molar Mass | 555.55 |
| Density | 1.372±0.06 g/cm3(Predicted) |
| Melting Point | 202 - 205°C (dec.) |
| Appearance | Form Solid, color Off-White |
| pKa | 13.23±0.70(Predicted) |
| Storage Condition | Amber Vial, -20°C Freezer, Under inert atmosphere |
| MDL | MFCD26793864 |
| Physical and Chemical Properties | Bioactive Rociletinib (CO-1686, AVL-301) is an irreversible, selective inhibition of mutant EGFR, acting on EGFRL858R/T790M and EGFRWT in cell-free assays with Ki of 21.5 nM and 303.3 nM, respectively. Phase 2. |
ROCILETINIB - Risk and Safety
| Risk Codes | R23 - Toxic by inhalation R25 - Toxic if swallowed R36 - Irritating to the eyes |
| Safety Description | 24 - Avoid contact with skin. |
| HS Code | 29335990 |
ROCILETINIB - Upstream Downstream Industry
ROCILETINIB - Introduction
CO-1686 (AVL-301) is an irreversible, mutation-selective EGFR inhibitor that acts on EGFRL858R/T790M and EGFRWT with a Ki of 21.5 nM and 303.3 nM, respectively. Phase 2.
Last Update：2022-10-16 17:13:42
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View History
Raw Materials for ROCILETINIB
2,4-Dichloro-5-trifluoromethylpyrimidine
tert-butyl (3-((2-chloro-5-(trifluoroMethyl)pyriMidin-4-yl)aMino)phenyl)carbaMate
N-(4-aminophenyl)acrylamide
5-Fluoro-2-nitroanisole
Acryloyl chloride
tert-butyl (3-((2-chloro-5-(trifluoroMethyl)pyriMidin-4-yl)aMino)phenyl)carbaMate
N-(4-aminophenyl)acrylamide
5-Fluoro-2-nitroanisole
Acryloyl chloride