R-7128
R-7128
CAS: 940908-79-2
Molecular Formula: C18H26FN3O6
R-7128 - Names and Identifiers
R-7128 - Physico-chemical Properties
| Molecular Formula | C18H26FN3O6 |
| Molar Mass | 399.41 |
| Density | 1.36 |
| Boling Point | 496.1±55.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 4.26±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | Mericitabine is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication. |
| Target | HCV NS5B polymerase, |
R-7128 - Reference
| Reference Show more | 1: Wedemeyer H, Forns X, Hézode C, Lee SS, Scalori A, Voulgari A, Le Pogam S, Nájera I, Thommes JA. Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies. PLoS One. 2016 Jan 11;11(1):e0145409. doi: 10.1371/journal.pone.0145409. eCollection 2016. PubMed PMID: 26752189; PubMed Central PMCID: PMC4713467. 2: Feng JY, Xu Y, Barauskas O, Perry JK, Ahmadyar S, Stepan G, Yu H, Babusis D, Park Y, McCutcheon K, Perron M, Schultz BE, Sakowicz R, Ray AS. Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus. Antimicrob Agents Chemother. 2015 Nov 23;60(2):806-17. doi: 10.1128/AAC.01922-15. PubMed PMID: 26596942. 3: Canini L, Guedj J, Chatterjee A, Lemenuel-Diot A, Smith PF, Perelson AS. Modelling the interaction between danoprevir and mericitabine in the treatment of chronic HCV infection. Antivir Ther. 2015 Nov 10. doi: 10.3851/IMP3006. [Epub ahead of print] PubMed PMID: 26555159. 4: Jensen DM, Brunda M, Elston R, Gane EJ, George J, Glavini K, Hammond JM, Le Pogam S, Nájera I, Passe S, Piekarska A, Rodriguez I, Zeuzem S, Chu T; ANNAPURNA study investigators. Interferon-free regimens containing setrobuvir for patients with genotype 1 chronic hepatitis C: a randomized, multicenter study. Liver Int. 2015 Oct 31. doi: 10.1111/liv.12997. [Epub ahead of print] PubMed PMID: 2 |
R-7128 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.504 ml | 12.518 ml | 25.037 ml |
| 5 mM | 0.501 ml | 2.504 ml | 5.007 ml |
| 10 mM | 0.25 ml | 1.252 ml | 2.504 ml |
| 5 mM | 0.05 ml | 0.25 ml | 0.501 ml |
Last Update：2024-01-02 23:10:35
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