PonesiMod
(2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propyliMino)-3-(o-tolyl)thiazolidin-4-one
CAS: 854107-55-4
Molecular Formula: C23H25ClN2O4S
PonesiMod - Names and Identifiers
PonesiMod - Physico-chemical Properties
| Molecular Formula | C23H25ClN2O4S |
| Molar Mass | 460.97 |
| Density | 1.30±0.1 g/cm3(Predicted) |
| Boling Point | 658.0±65.0 °C(Predicted) |
| pKa | 13.38±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Relative to the potency of S1P, ponesimod had a 4.4-fold higher regulatory efficacy on the human recombinant receptor S1P1 and a 150-fold lower regulatory efficacy on S1P3. Thus, ponesimod is approximately 650-fold more selective for S1P1 than the natural ligand relative to S1P3. |
| In vivo study | Ponesimod is a novel, potent and selective S1P1 receptor agonist. Ponesimod prevents edema formation, accumulation of inflammatory cells, and release of cytokines in the skin of delayed-type allergic mice. Ponesimod can prevent the increase of toe volume and joint inflammation in rats with adjuvant arthritis. Selective activation of S1P1 with ponesimod leads to a decrease in the number of peripheral blood lymphocytes and prevents lymphocyte-mediated tissue inflammation. ponesimod may exert its utility in animal models of autoimmunity and human autoimmune diseases through its effect on T cell and B cell blood cell numbers. Thus, ponesimod may be a new therapeutic option for the treatment of autoimmune diseases. Within one week after discontinuation of treatment, Ponesimod was eliminated and its medicinal effect was rapidly reversible. |
PonesiMod - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.169 ml | 10.847 ml | 21.693 ml |
| 5 mM | 0.434 ml | 2.169 ml | 4.339 ml |
| 10 mM | 0.217 ml | 1.085 ml | 2.169 ml |
| 5 mM | 0.043 ml | 0.217 ml | 0.434 ml |
Last Update：2024-01-02 23:10:35
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