Parachlorophenol

Parachlorophenol - Names and Identifiers

Name	P-Chlorophenol
Synonyms	applied3-78 Applied 3-78 p-Chlorfenol p-chloro-pheno 4-chlorophenol 4-chloro-pheno P-Chlorophenol 4-chloro phenol 4-chloro-phenole Parachlorophenol P-CHLORO PHENOL Chlorophenol, 4- Para chlorophenol Phenol, p-chloro- Phenol, 4-chloro- p-chlorophenicacid chlorophenols,solid p-chlorfenol(czech) 4-Chlorophenol(form2) 4-Hydroxychlorobenzene 4-Chlorophenol solution 4-chloro-1-hydroxybenzene Benzene, 1-chloro-4-ethoxy-
CAS	106-48-9
EINECS	203-402-6
InChI	InChI=1/C8H9ClO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2H2,1H3

Parachlorophenol - Physico-chemical Properties

Molecular Formula	C6H5ClO
Molar Mass	128.56
Density	1.306 g/mL at 25 °C (lit.)
Melting Point	42-45 °C
Boling Point	220 °C (lit.)
Flash Point	240°F
Water Solubility	2.7 g/100 mL (20 ºC)
Solubility	ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
Vapor Presure	1 mm Hg ( 49.8 °C)
Vapor Density	4.43 (vs air)
Appearance	Low Melting Crystalline Mass
Color	White to pale yellow
Odor	Phenolic like 30 ppm
Merck	14,2154
BRN	507004
pKa	9.18(at 25℃)
Storage Condition	2-8°C
Stability	Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents, iron.
Sensitive	Air Sensitive
Refractive Index	1.5579
Physical and Chemical Properties	Pure character is white crystal (industrial product is yellow or pink crystal.) There is an unpleasant pungent odor. melting point 43~44 ℃ boiling point 220 ℃ relative density 1.2651 refractive index 1.5579 flash point 121 ℃ solubility almost insoluble in water, soluble in benzene, ethanol, ether, glycerol, chloroform, fixed oil and volatile oil.
Use	For the synthesis of neutral brilliant green BL dye, pharmaceutical and pesticide, can also be used as refined mineral oil solvent

Parachlorophenol - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R50 - Very Toxic to aquatic organisms
Safety Description	S28 - After contact with skin, wash immediately with plenty of soap-suds. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - S24/25 - Avoid contact with skin and eyes. S60 - This material and its container must be disposed of as hazardous waste. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	UN 2020 6.1/PG 3
WGK Germany	2
RTECS	SK2800000
FLUKA BRAND F CODES	10-23
TSCA	Yes
HS Code	29081000
Hazard Class	6.1
Packing Group	III
Toxicity	LD50 orally in rats: 0.67 g/kg (Deichmann)

Parachlorophenol - Upstream Downstream Industry

Raw Materials	Phenol
Downstream Products	Triadimefon

Parachlorophenol - Nature

Open Data Verified Data

The colorless needle-like crystal has an unpleasant odor. The melting point was 42-43 °c. Boiling point 217 °c. Refractive index 1. 5571( 40 °c). The relative density was 1.2278. Slightly soluble in water, soluble in benzene, ethanol, ether, glycerol and caustic liquid.

Last Update：2025-06-10 22:55:16

Parachlorophenol - Preparation Method

Open Data Verified Data

This product has a variety of methods, there are mainly the following:

the phenol direct chlorination method takes phenol as the raw material, and is divided into the following three methods according to the different chlorinating agents and solvents used:(1) the sulfuryl chloride method uses phenol as the raw material and sulfuryl chloride as the chlorinating agent, prepared under the action of iron catalyst. The yield of p-chlorophenol was 70% ~ 75%. Consumption quota: phenol It. Sulfuryl chloride 2.Otlt. (2) benzene solvent method with benzene as solvent, chlorine as chlorinating agent, by phenol direct chlorination of this product. (3) solvent-free chlorination method using iron, bromine and other catalysts, the chlorine gas into the molten phenol, direct chlorination to produce a chlorophenol. After washing, the reaction solution was distilled under reduced pressure to collect a fraction having a p-chlorophenol content of ≥ 95%. The rate of phenol (total ortho/para position) is ≥ 95%, the rate of chlorine is 95%, the ratio of Para/Ortho is 3~4, and the product content is ≥ 98%. Consumption quota: phenol 0. 77T, chlorine 0.58tlt; Hydrogen chloride 0. 28tlt.
the hydrolysis method of p-dichlorobenzene is prepared by using p-dichlorobenzene as a raw material and water, alcohol or benzene as a solvent.
p-chloroaniline was obtained by diazotization and hydrolysis.
p-aminophenol was obtained by diazotization and substitution.

Last Update：2022-01-01 10:41:59

Parachlorophenol - Application

Open Data Verified Data

This product is mainly used in pesticides, pharmaceuticals, dyes, plastics and other industries, also used as ethanol colorant, refined mineral oil selective solvent, microscopic analysis; Agricultural industry is mainly used for the synthesis of rust, trimethoprim, wool bactericide, anti-falling element, phosphorus of insect, phosphorus of poison rat, insecticide, etc.; Dye industry is used to make 1,4-= hydroxyanthraquinone, 1,4-= aminoquinone, P-aminophenol and hydroquinone; Pharmaceutical industry for the carboxylation of 5-chloro -2-Hydroxybenzoic acid sodium, synthesis of p-chlorophenoxy isobutyric acid and other drugs; Also used in the synthesis of antioxidant BHA (butyl hydroxy anisole) and so on.

Last Update：2025-08-19 16:24:40

Parachlorophenol - Safety

Open Data Verified Data

screw mouth glass bottle, glass bottle with pressure Mouth of Iron cover, plastic bottle or metal barrel (can) outer wood box. Store in a cool, ventilated room. Keep away from fire and heat source. Protection from direct sunlight. Handling should be light and light unloading, to prevent packaging and container damage. Attention should be paid to personal protection in sub-packing and handling operations.

Last Update：2025-06-10 22:55:16

Parachlorophenol - Reference Information

olfactory Threshold	30 ppm
LogP	2.5 at 35℃
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	p-chlorophenol is a white crystalline (yellow to pink when not pure)-like substance with an unpleasant odor. Soluble in water, ethanol, benzene and ether. It can volatilize with water vapor and has strong irritation. The maximum allowable concentration in the air of the workshop is 1 mg/m 3. The oral LD50 of rats was 261 mg/kg.
Application	p-chlorophenol is mainly used in pesticides, pharmaceuticals, dyes, plastics and other industries, and is also used as an ethanol colorant, refined mineral oil selective solvent, microscopic analysis, etc. Phenol is an important raw material for the production of certain resins, fungicides, preservatives and drugs (such as aspirin). It can also be used for the treatment of Disinfection surgical instruments and excreta, skin sterilization, itching and otitis media.
Application	used in the synthesis of dye neutral brilliant green BL, medicinal antoamine and pesticide, etc, it can also be used as a solvent for refined mineral oil microscopic analysis, pharmaceutical and dye intermediates, alcohol denaturants, solvents. for microscope analysis; For the synthesis of dye neutral brilliant green BL, pharmaceutical Antoin and pesticides, can also be used as a solvent for refined mineral oil; For pesticides, pharmaceuticals, dyes, plastics and other industries, also used as ethanol colorant, refined mineral oil selective solvent, microscopic analysis, etc. microscopic analysis, pharmaceutical and dye intermediates, alcohol denaturant, solvent. This product is mainly used for pesticides; Medicine; Dyes; Plastics and other industries, also used as ethanol colorants; Refined mineral oil selective solvent; Microscopic analysis; Agricultural industry is mainly used for the synthesis of rust; Trimethoprim; wool bactericide; Anti-fall agent; P. Falciparum; P. Poison; Insecticide, etc., used in the manufacture of pesticide bactericide 5, 5 'dichloro-2, 2' dihydroxydiphenylmethane and plant growth promoter; Dye industry for the preparation of 1, 4-dihydroxyanthraquinone, 1, 4-diaminoanthraquinone, p-aminophenol and hydroquinone; the pharmaceutical industry is used to carboxylate sodium 5-chloro-2-hydroxybenzoate, synthesize p-chlorophenoxyisobutyric acid and other drugs; Also used to synthesize antioxidant BHA (butyl hydroxyanisole) and so on.
production methods	This product has a variety of production methods, there are mainly the following: 1. Phenol direct chlorination method with phenol as raw material, according to the different chlorinating agent and solvent used, is divided into the following three methods:(1) sulfuryl chloride method of phenol heating and melting, cooling to 40 deg C, slowly add sulfuryl chloride, about 40-45min to add, and then stirred for 4H, heated to 30-40 ℃ for 4h,40-45 ℃ for 4H, the reaction tail gas is absorbed by alkali solution, the reaction is cooled to room temperature, water, the 10% sodium carbonate solution and water were sequentially washed and distilled under reduced pressure to obtain p-chlorophenol from 110-115 ℃(2.67kPa) fraction. The yield of p-chlorophenol was 70%-75%. At the same time, 25-30% of the by-product O-chlorophenol was generated. About 1000kg of phenol and about 2000kg of sulfuryl chloride are consumed per ton of p-chlorophenol. (2) benzene solvent method with benzene as solvent, chlorine as chlorinating agent, by phenol direct chlorination of this product. (3) solvent-free chlorination method using iron, bromine and other catalysts, the chlorine gas into the molten phenol, direct chlorination to produce a chlorophenol. After washing, the reaction solution was distilled under reduced pressure to collect a fraction having a p-chlorophenol content of ≥ 95%. The rate of phenol (total ortho/para position) is ≥ 95%, the rate of chlorine is 95%, the ratio of Para/Ortho is 3-4, and the product content is ≥ 98%. Raw material consumption quota: phenol 0.77t/t, chlorine 0.58t/t. The by-product hydrogen chloride was 0.28t/t. The hydrolysis of p-chlorobenzene is prepared by using p-dichlorobenzene as raw material and water or alcohol or benzene as solvent. 3. Chlorinating solution of O-chlorophenol and p-chlorophenol mixed with 2, 4-dichlorophenol obtained from the chlorination of sodium phenolate. The high boiling point fraction at 85-132 °c (2.0kPa) was collected by fractional distillation under reduced pressure, cooled to below 10 °c, and then p-chlorophenol was precipitated and separated. The yield was about 25%. 4. Derived from p-aminophenol by diazotization, cuprous chloride replacement. From p-chloroaniline by diazotization, hydrolysis, elimination and derived.
category	toxic substances
toxicity grade	high toxicity
Acute toxicity	intraperitoneal-rat LD50: 281 mg/kg; Oral-mouse LD50: 367 mg/kg
stimulation data	Skin-rabbits 2 mg/24 h moderate; eye-rabbit 0.25 mg/24 h severe
flammability hazard characteristics	flammable in case of open flame; Toxic chloride fumes from combustion
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; It is stored separately from oxidants and food additives
extinguishing agent	carbon dioxide, foam, sand, water mist.
Occupational Standard	TWA 1 mg/m3
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)