PH-797804
PH-797804
CAS: 586379-66-0
Molecular Formula: C22H19BrF2N2O3
PH-797804 - Names and Identifiers
PH-797804 - Physico-chemical Properties
| Molecular Formula | C22H19BrF2N2O3 |
| Molar Mass | 477.3 |
| Density | 1.51 |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 20-25°C |
| In vitro study | PH-797804 acts on the human monocytic U937 cell line, blocking LPS-induced TNF-α production and p38 kinase activity with IC50 of 5.9 and 1.1 nM. No Inhibitory effect was observed on the JNK pathway (c-Jun phosphorylation) or ERK pathway (ERK phosphorylation) in U937 cells at concentrations up to 1 μm. PH-797804 inhibits RANKL-and M-CSF-induced osteoclast formation in primary rat bone marrow cells in a concentration-dependent manner with IC50 = 3 nM. PH-797804 IC50 values greater than 200 μm for the following targets: CDK2, ERK2, IKK1, IKK2, IKKi, MAPKAP2, MAPKAP3, MKK7 (>100 μm), MNK, MSK (>164 μm), PRAK, RSK2, and TBK1, illustrate that the activity of PH-797804 is specific. |
| In vivo study | The acute inflammatory response induced by systemic administration of Endotoxin to rats and cynomolgus monkeys can be effectively inhibited by PH-797804 by oral administration. PH-797804 treatment model disease model, treated for 10 days, has strong anti-inflammatory activity, acting on streptococcal cell wall-induced arthritis and collagen-induced arthritis in rats and mice, significantly reducing joint inflammation and related bone loss. Dose-response analysis showed that the ED50 for rats and cynomolgus monkeys were 0.07 mg/kg and 0.095 mg/kg, respectively. PH-797804 inhibited LPS-induced TNF-α, IL-6, and MK-2 activity in a human Endotoxin challenge model in a dose-and concentration-dependent manner. |
PH-797804 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.095 ml | 10.476 ml | 20.951 ml |
| 5 mM | 0.419 ml | 2.095 ml | 4.19 ml |
| 10 mM | 0.21 ml | 1.048 ml | 2.095 ml |
| 5 mM | 0.042 ml | 0.21 ml | 0.419 ml |
Last Update：2024-01-02 23:10:35
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Featured ProductsSpot supply
Product Name: PH-797804 Visit Supplier Webpage Request for quotationCAS: 586379-66-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: PH-797804 Request for quotationCAS: 586379-66-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: PH-797804 Visit Supplier Webpage Request for quotationCAS: 586379-66-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: PH-797804 Visit Supplier Webpage Request for quotationCAS: 586379-66-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: PH-797804 Visit Supplier Webpage Request for quotationCAS: 586379-66-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: PH-797804 Visit Supplier Webpage Request for quotation
CAS: 586379-66-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 586379-66-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
PH-797804
L-Alanine
1,3-Propanedicarboxamide
1569-69-3
sodiumdiclofenac
402-42-6
131926-99-3
150725-87-4
21480-43-3
220352-39-6
L-Alanine
1,3-Propanedicarboxamide
1569-69-3
sodiumdiclofenac
402-42-6
131926-99-3
150725-87-4
21480-43-3
220352-39-6