PFI-2
PFI-2
CAS: 1627676-59-8
Molecular Formula: C23H25F4N3O3S
PFI-2 - Names and Identifiers
PFI-2 - Physico-chemical Properties
| Molecular Formula | C23H25F4N3O3S |
| Molar Mass | 499.52 |
| Density | 1.371±0.06 g/cm3(Predicted) |
| Boling Point | 642.7±65.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 8.95±0.20(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | The inhibitory activity of (R)-PFI-2 against human SETD7 was 500-fold higher than that of its isomer,(S)-PFI-2. In the cellular environment, through direct interaction with SETD7, it affects the localization of Yes-related protein and the deletion of phenotypic Setd7 gene in the Hippo pathway signal. |
PFI-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.002 ml | 10.01 ml | 20.019 ml |
| 5 mM | 0.4 ml | 2.002 ml | 4.004 ml |
| 10 mM | 0.2 ml | 1.001 ml | 2.002 ml |
| 5 mM | 0.04 ml | 0.2 ml | 0.4 ml |
Last Update：2024-01-02 23:10:35
PFI-2 - Introduction
PFI-2 is a compound known as 1-((3S,4S)-3-amino -4-methyl -5-(5-chloro [1,2,4] triazin-7-yl) pent-3-enyl)-1H-pyrazole-4-methanone. The following is a description of the nature, use, preparation and safety information of the PFI-2:
1. Nature:
PFI-2 is a solid powder with a chemical formula of C19H18ClN7O and a relative molecular mass of 395.85g/mol. The compound is a white to yellow crystal, stable at room temperature.
2. Use:
PFI-2 is a specific inhibitor, mainly used in the study of Histone methyltransferases (HMTs). PFI-2 can selectively inhibit HMTs enzyme activity, thereby affecting chromatin and epigenetic modifications. Therefore, PFI-2 has important application value in epigenetic research and drug discovery.
3. Preparation method:
There is no clear public literature on the synthesis of PFI-2, so the specific preparation method is not known in the public domain.
4. Safety Information:
The use of PFI-2 should be strictly in accordance with laboratory safety procedures to ensure the safety of laboratory personnel. Need to pay attention to the following points:
- PFI-2 may be irritating and hazardous and should avoid contact with skin, eyes and respiratory tract.
-Wear appropriate personal protective equipment, such as lab gloves, goggles, and protective masks, while operating the PFI-2.
-When storing and handling PFI-2, follow the regulations for the disposal of chemical waste.
-If PFI-2 is ingested or inhaled, seek medical attention immediately and bring the compound's label or safety data sheet.
1. Nature:
PFI-2 is a solid powder with a chemical formula of C19H18ClN7O and a relative molecular mass of 395.85g/mol. The compound is a white to yellow crystal, stable at room temperature.
2. Use:
PFI-2 is a specific inhibitor, mainly used in the study of Histone methyltransferases (HMTs). PFI-2 can selectively inhibit HMTs enzyme activity, thereby affecting chromatin and epigenetic modifications. Therefore, PFI-2 has important application value in epigenetic research and drug discovery.
3. Preparation method:
There is no clear public literature on the synthesis of PFI-2, so the specific preparation method is not known in the public domain.
4. Safety Information:
The use of PFI-2 should be strictly in accordance with laboratory safety procedures to ensure the safety of laboratory personnel. Need to pay attention to the following points:
- PFI-2 may be irritating and hazardous and should avoid contact with skin, eyes and respiratory tract.
-Wear appropriate personal protective equipment, such as lab gloves, goggles, and protective masks, while operating the PFI-2.
-When storing and handling PFI-2, follow the regulations for the disposal of chemical waste.
-If PFI-2 is ingested or inhaled, seek medical attention immediately and bring the compound's label or safety data sheet.
Last Update：2024-04-09 20:49:11
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QQ: 2881950922
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Tel: 609-228-6898
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tech@medchemexpress.com
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Product Name: PFI-2 Visit Supplier Webpage Request for quotation
CAS: 1627676-59-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1627676-59-8
Tel: 18301782025
Email: 3008007409@qq.com
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