PARAPLATIN
1,1-Cyclobutanedicarboxylatodiammineplatinum (II)
CAS: 41575-94-4
Molecular Formula: C6H12N2O4Pt
PARAPLATIN - Names and Identifiers
PARAPLATIN - Physico-chemical Properties
| Molecular Formula | C6H12N2O4Pt |
| Molar Mass | 371.25 |
| Melting Point | 228-230°C |
| Water Solubility | Soluble in water. |
| Solubility | Sparingly soluble in water, very slightly soluble in acetone and in ethanol (96 per cent). |
| Appearance | White solid |
| Color | white |
| Merck | 14,1822 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to light |
| MDL | MFCD00070464 |
| Physical and Chemical Properties | White flocculent loose powder, sponge-like lumps, odorless. Soluble in water. It is easy to decompose when exposed to light. Acute toxic LD50 mice (mg/kg):150 intraperitoneal injection and 140 intravenous injection. Acute toxicity LD50 rats (mg/kg):85 intravenous injection. |
| Use | Is the second generation of platinum anticancer drugs, its activity and cisplatin, biochemical properties and activity spectrum is similar, but the side effects were significantly lower than Cisplatin |
PARAPLATIN - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R46 - May cause heritable genetic damage R61 - May cause harm to the unborn child R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R42/43 - May cause sensitization by inhalation and skin contact. R20/21 - Harmful by inhalation and in contact with skin. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | TP2300000 |
| HS Code | 28439000 |
| Toxicity | LD50 in mice (mg/kg): 150 i.p., 140 i.v.; in rats (mg/kg): 85 i.v. (Lelieveld) |
PARAPLATIN - Upstream Downstream Industry
| Raw Materials | Silver sulfate Barium hydroxide |
PARAPLATIN - Reference
| Reference Show more | 1. [IF=7.46] Ying Zhang et al."A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states."Sensor Actuat B-Chem. 2020 Dec;324:128696 |
PARAPLATIN - Nature
Open Data Verified Data
white powder or crystalline powder, odorless. Slightly soluble in water, insoluble in ethanol, acetone, chloroform or ether. Easily decomposed in light. When the temperature is higher than 120 ℃, the appearance gradually changes color, and the decomposition temperature is 247~258 ℃. Solid carboplatin is relatively stable to light, unstable in its aqueous solution, prone to degradation, degradation products of dihydramine platinum dihydrate, UV irradiation accelerates its degradation. Carboplatin and aluminum can produce black precipitation, should not be directly contacted.
Last Update：2025-06-10 22:55:16
PARAPLATIN - Preparation Method
Open Data Verified Data
potassium chloroplatinate is reacted with hydrazine hydrochloride and potassium iodide to obtain cisplatin iodide, which can be purified by recrystallization from a mixture of dimethylformamide and ethanol. Cisplatin cisplatin iodide was added into water, and Silver sulfate was slowly added dropwise. The reaction was completed. The insoluble matter was filtered off, and 1,1-ring barium butane dicarboxylate was slowly added to the filtrate, reacted at room temperature, allowed to stand, filtered, and the filtrate was evaporated to dryness. The resulting solid was washed with water and ethanol, respectively. After drying, carboplatin was obtained.
Last Update：2025-06-10 22:55:16
PARAPLATIN - Standard
Authoritative Data Verified Data
This product is cis -1,1-cyclobutane two diamino platinum acid. The content of C6H12N204Pt shall be between 98.0% and 102.0% calculated as the dry product.
Last Update：2024-01-02 23:10:35
PARAPLATIN - Trait
Authoritative Data Verified Data
- This product is white powder or crystalline powder; Odorless.
- This product is slightly soluble in water, insoluble in ethanol, acetone, three gas methane or ether.
Last Update：2022-01-01 11:37:20
PARAPLATIN - Application
Open Data Verified Data
developed by the U. S. Company Johnson-Matthy, launched in 1986. Second-generation platinum complex antineoplastic agents. The anti-tumor spectrum and anti-tumor activity were similar to cisplatin, but the water solubility was better than Cisplatin, and the toxicity to kidney was lower. Because of its strong anti-tumor activity, gastrointestinal reaction and low renal toxicity, it has been widely used. It can combine with DNA to form a cross bond, which destroys the function of DNA and makes it unable to replicate and synthesize. It is a non-specific drug of cell cycle. Mainly applicable to ovarian cancer, lung cancer, head and neck cancer, germ cell tumors, thyroid cancer, cervical cancer, bladder cancer, etc. Intravenous infusion should avoid direct sun exposure, it is best to use black paper to shield light, otherwise easy to decompose failure. Combined with other anticancer drugs, the curative effect is better.
Last Update：2025-08-19 16:24:40
PARAPLATIN - Differential diagnosis
Authoritative Data Verified Data
- take about 5mg of this product, add a small amount of thiourea, add an appropriate amount of water, heat, the solution appears yellow.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 593).
Last Update：2022-01-01 11:37:20
PARAPLATIN - Safety
Open Data Verified Data
mouse LDso (mg/kg): 150 intraperitoneal injection, 140 intravenous injection. Rat LD50(mg/kg): 85 intravenous injection.
Last Update：2022-01-01 09:09:14
PARAPLATIN - Exam
Authoritative Data Verified Data
platinum content
take about 0.5g of this product, weigh it precisely, and burn it to constant weight at 0841 ° C according to the method of burning residue inspection (General Rule 400, but without sulfuric acid), the weight of the obtained residue was the weight of platinum contained in the Test amount. According to the dry product calculation, the molybdenum content of this product should be 52.0% ~ 53.0%.
acid reduction
take 80mg of this product, Add 10ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 5.5~7.5.
clarity of the solution
take 80mg of this product, add 10ml of water to dissolve, the solution should be clear.
1, 1-cyclobutane dicarboxylic acid
take this product, add mobile phase to dissolve and dilute to make a solution containing lmg per lml as a test solution (ready to use new system); Take 2mg of 1, 1-cyclobutane dicarboxylic acid, in a 200ml measuring flask, 1 ml of the test solution was added precisely, diluted to the scale with the mobile phase, and shaken to serve as a control solution. According to the test of high performance liquid chromatography (General rule 0512), the silica gel bonded with eighteen alkyl silane was used as the filler, and tetrabutylammonium hydrogen sulfate buffer solution (8.5g tetrabutylammonium hydrogen sulfate, 80ml of water was added to dissolve, 3.4 of phosphoric acid was added, and the pH value was adjusted to 7.55 with 10 mol/L sodium hydroxide solution. The mobile phase was water-acetonitrile (20:880:100), the theoretical plate number calculated from the carboplatin peak is not less than 5000, the degree of separation between the 1, 1-cyclobutane dicarboxylic acid peak and the carboplatin peak should be greater than 2.5. Take 100 u1 of each of the test solution and the control solution respectively, inject the human liquid chromatograph, record the chromatogram to 4 times of the retention time of the main component peak. If there is a 1, 1-cyclobutane dicarboxylic acid peak in the chromatogram of the test solution, the peak area multiplied by 7.96 shall not be greater than the carboplatin Peak area of the test solution (0.5%).
Related substances
take this product, add water to dissolve and dilute to make a solution containing about 1 mg per 1 ml, as a test solution; Take an appropriate amount of precision, A solution containing 10ug per 1 ml was prepared as a control solution by quantitative dilution with water. According to the chromatographic conditions under the content determination item, 10 u1 of the test solution and 10 u1 of the control solution are accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be more than 2 times (2.0%) of the main peak area of the control solution.
acid-soluble barium salt
take 80mg of this product, add 10ml of water to dissolve, add 2ml of dilute hydrochloric acid, boil for 5 minutes, add evaporated water, cool, filter with filter paper washed with hydrochloric acid solution (1-40), the residue and funnel are washed with a small amount of water (about 2ml), the washing liquid and the filtrate are combined, 0.5 of dilute sulfuric acid is added, and the mixture is left for 30 minutes without turbidity.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
Last Update：2022-01-01 11:37:21
PARAPLATIN - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with eighteen alkyl silane was used as the filler; Water was used as the mobile phase; The detection wavelength was 229nm. The number of theoretical plates is not less than 3000 based on the carboplatin peak.
assay
take an appropriate amount of this product, accurately weigh it, add water to dissolve and quantitatively dilute it to make a solution containing about 0.2mg per lml, as a sample solution, and inject 10ul into the liquid chromatograph with precise amount, the chromatogram was recorded; Another carboplatin reference substance was taken for determination by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:37:22
PARAPLATIN - Category
Authoritative Data Verified Data
antineoplastic agents.
Last Update：2022-01-01 11:37:22
PARAPLATIN - Storage
Authoritative Data Verified Data
It was sealed and kept in a cool and dark place.
Last Update：2022-01-01 11:37:22
PARAPLATIN - Carboplatin injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of carboplatin containing carboplatin (C6H12N204Pt) between 90.0% and 105.0% of label load.
trait
This product is colorless to yellowish clear liquid.
identification
- take an appropriate amount of this product (about 5mg of carbo-cobalt), add a little thiourea, and heat, the solution appears yellow.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- the pH value should be 4.5 to 7.0 (General O631).
- the color of this product, compared with the yellow No. 2 Standard Colorimetric liquid (General Principles 0901 first method), should not be deeper.
- 1, 1-cyclobutane dicarboxylic acid precise quantity appropriate amount of this product is diluted with mobile phase to prepare a solution containing 1 mg of carboplatin per 1ml, as a test solution (ready for new preparation 1, 1 mg of 1-cyclobutane dicarboxylic acid was placed in a 100ml measuring flask, and 1ml of the test solution was added with precision, diluted to the scale with the mobile phase, and shaken to obtain a control solution. According to the test of high performance liquid chromatography (General rule 0512), the silica gel bonded with eighteen alkyl silane was used as the filler, and tetrabutylammonium hydrogen sulfate buffer solution (8.5g tetrabutylammonium hydrogen sulfate) was used to dissolve the solution, and 80ml of water was added, 3.4 of phosphoric acid was added, and the pH value was adjusted to 7.55 with 10mol/L sodium hydroxide solution. The mobile phase was water-acetonitrile (20:880:100), and the detection wavelength was 220nm, the theoretical plate number shall not be less than 5000, and the degree of separation between the peak of 1, 1-cyclobutane dicarboxylic acid and the peak of carboplatin shall be greater than 2.5 calculated by the carboplatin peak. The sample solution and the control solution were respectively injected into the liquid chromatograph, and the chromatograms were recorded. If there is a 1, 1-cyclobutane dicarboxylic acid peak in the chromatogram of the test solution, the peak area multiplied by 7.96 shall not be greater than the control solution carboplatin peak area (1.0%).
- the related substances were protected from light. Take this product and dilute it with water to make a solution containing about 1 mg of carboplatin per 1ml as a test solution. Take 1ml for precision measurement, put it in a 50ml measuring flask, dilute it to the scale with water, and shake it well, as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (2.0%).
- bacterial endotoxin take this product, according to the inspection (General 1143), each 1 mg of carboplatin containing endotoxin should be less than 0.50 EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- light-shielding operation. Determined by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Water as mobile phase; Detection wavelength of 229nm. The number of theoretical plates is not less than 3000 based on the carboplatin peak.
- determination precision: take an appropriate amount of this product and quantitatively dilute it with water to make a solution containing about 0.2mg of carboplatin per 1 ml, as a test solution, take 10 u1 for precision measurement, and inject it into human liquid chromatograph, record the chromatogram; Take an appropriate amount of the reference compound of carbo-europium, weigh it precisely, dissolve it with water and dilute it quantitatively to make a solution containing about 0.2mg per 1 ml. According to the external standard method to calculate the peak area, that is.
category
Same as Capper.
specification
- lOml:50mg
- 10ml:lOOmg
Last Update：2022-01-01 11:37:23
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Raw Materials for PARAPLATIN