P-TOLUIDINE
p-Toluidine
CAS: 106-49-0
Molecular Formula: C7H9N
P-TOLUIDINE - Names and Identifiers
P-TOLUIDINE - Physico-chemical Properties
| Molecular Formula | C7H9N |
| Molar Mass | 107.15 |
| Density | 0.973g/mLat 25°C(lit.) |
| Melting Point | 41-46°C(lit.) |
| Boling Point | 200°C(lit.) |
| Flash Point | 192°F |
| Water Solubility | 1.1 g/100 mL |
| Solubility | Soluble in ethanol, pyridine, diethyl ether, acetone, carbon tetrachloride, methanol, carbon disulfide, oils and dilute acids. |
| Vapor Presure | 0.26 mm Hg ( 25 °C) |
| Vapor Density | 3.9 (vs air) |
| Appearance | powder |
| Specific Gravity | 0.962 |
| Color | tan to brown |
| Exposure Limit | TLV-TWA skin 2 ppm (～9 mg/m3) (ACGIH);Suspected Human Carcinogen (ACGIH). |
| Merck | 14,9536 |
| BRN | 471281 |
| pKa | 5.08(at 25℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. |
| Sensitive | Air & Light Sensitive |
| Explosive Limit | 6.6% |
| Refractive Index | 1.5636 |
| Physical and Chemical Properties | Density 0.962 melting point 41-46°C boiling point 200°C refractive index 1.5636 flash point 87°C water-soluble 1.1g/100 mL |
| Use | Used as dye, medicine, pesticide intermediates |
P-TOLUIDINE - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R40 - Limited evidence of a carcinogenic effect R43 - May cause sensitization by skin contact R50 - Very Toxic to aquatic organisms |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - |
| UN IDs | UN 3451 6.1/PG 2 |
| WGK Germany | 2 |
| RTECS | XU3150000 |
| FLUKA BRAND F CODES | 8-23 |
| TSCA | Yes |
| HS Code | 38220000 |
| Hazard Class | 6.1 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 336 mg/kg LD50 dermal Rabbit 890 mg/kg |
P-TOLUIDINE - Upstream Downstream Industry
| Downstream Products | 3-Methyl-1-phenyl-2-pyrazolin-5-one 4-fluorobenzotrifluoride p-Fluorotoluene 6-Amino-m-toluenesulfonic acid |
P-TOLUIDINE - Nature
Open Data Verified Data
white, shiny, lamellar crystals. Flammable. Relative density 0.9619. The melting point of 44~45. Boiling point 200.2 °c. Flash point 87.2 °c. Refractive index 5534. Slightly soluble in water, soluble in ethanol, ether, carbon disulfide and oil. Soluble in dilute inorganic acid and salt formation.
Last Update：2025-06-10 22:55:16
P-TOLUIDINE - Preparation Method
Open Data Verified Data
p-nitrotoluene at 124~126 ℃, 0. Under 2MPa gauge pressure, P-toluidine was prepared by reduction with sodium sulfide. The reaction liquid was allowed to stand and layered, and the aqueous layer was separated, and then distilled under reduced pressure, condensed, crystallized and dried to obtain a finished product.
Last Update：2022-01-01 10:50:59
P-TOLUIDINE - Application
Open Data Verified Data
It is mainly used as a dye intermediate for producing a red color group GL, toluidine Red Lake, basic fuchsin, tolyl peritol acid, 4-aminotoluene 3 sulfonic acid, triphenylmethane dye, oxazine dye and the like. It is also an intermediate of pyrimethamine in medicine.
Last Update：2025-08-19 16:24:40
P-TOLUIDINE - Safety
Open Data Verified Data
- This product is toxic. Carcinogenicity. The lowest toxic concentration in the central nervous system of rabbits was 0. 04mg/L. In the skin contact after 40min, the symptoms of poisoning. The maximum allowable concentration in air is 3mg/m3. The toxicity was similar to that of o-toluidine. See o-toluidine.
- It is packed in iron drum with a net weight of 180kg per drum. Storage in a dry, ventilated place, heat, moisture, sunscreen. According to the provisions of toxic substances storage and transportation.
Last Update：2025-06-10 22:55:16
P-TOLUIDINE - Reference Information
| LogP | 1.39-1.44 at pH7.4-7.5 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | p-toluidine, organic compound, colorless, lustrous crystals, slightly soluble in water, soluble in ethanol, ether, benzene, hydrochloric acid, toxic, is a strong methemoglobin forming agent, and can stimulate the bladder and urethra, can cause hematuria. In the industry, P-Toluidine is mainly used as a dye intermediate and a pharmaceutical intermediate of ethylamine. |
| Application | p-Toluidine is the dye Red radical GL, methylamine Red Lake, basic fuchsin, methyl pericolic acid and 4-amino toluene -3-sulfonic acid, triphenylmethane dyes and oxazine dyes, drug pyrimethamine, pesticide terazon and other product intermediates. |
| Use | used as analytical reagent, also used in the synthesis of dyes mainly as dye intermediates, used in the preparation of red GL, methylamine Red Lake, basic fuchsin, methyl-pericolic acid and 4-aminotoluane-3-sulfonic acid, triphenylmethane dye and oxazine dye, etc. It is also used as an intermediate of pyrimethamine for medicine, pesticide trimethoprim and other products. It is mainly used as a dye intermediate to make Red Group GL, methylamine Red Lake, basic fuchsin, methyl periodic acid and 4-aminotolu-3-sulfonic acid, triphenylmethane dye and oxazine dye. It is also used as an intermediate of pyrimethamine for medicine, pesticide trimethoprim and other products. Used as dye, medicine, pesticide intermediates; Used as analytical reagents, but also for the synthesis of dyes spectrophotometric determination of gold, titanium (III), tungsten. Gold, silver, osmium, platinum, nitrate, nitrite, phloroglucinol and lignin were assayed. Carboxylic acids and sulfonic acids were determined. Solvent for determination of molecular weight. Organic synthesis is used for the production of 4B acids and synthetic dyes. |
| production method | p-toluidine was prepared by reducing P-nitrotoluene with sodium sulfide at 124-126 ℃ and 0.2MPa gauge pressure, the reaction liquid was allowed to stand and layered, and the aqueous layer was removed, and then distilled under reduced pressure, condensed, crystallized and dried to obtain the finished product |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 336 mg/kg; Oral-mouse LD50: 330 mg/kg |
| stimulation data | Skin-rabbits 500 mg/24 h severe; eye-rabbit 20 mg/24 h moderate |
| flammability hazard characteristics | open flame, high heat, flammable oxidant; combustion releases toxic NOx smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from oxidants and food additives |
| extinguishing agent | dry powder, foam, carbon dioxide, sand, water mist |
| Occupational Standard | TWA 9 mg/m3; Tel 20 mg/m3 |
| spontaneous combustion temperature | 899 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 19:05:07
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View History
Downstream Products for P-TOLUIDINE
3-Methyl-1-phenyl-2-pyrazolin-5-one
4-fluorobenzotrifluoride
p-Fluorotoluene
6-Amino-m-toluenesulfonic acid
4-fluorobenzotrifluoride
p-Fluorotoluene
6-Amino-m-toluenesulfonic acid