Oxytetracycline
Oxytetracycline
CAS: 79-57-2
Molecular Formula: C22H24N2O9
Oxytetracycline - Names and Identifiers
Oxytetracycline - Physico-chemical Properties
| Molecular Formula | C22H24N2O9 |
| Molar Mass | 460.43 |
| Density | 1.6340 |
| Melting Point | 183 °C |
| Boling Point | 565.29°C (rough estimate) |
| Specific Rotation(α) | -223 º (c=1 0.03N HCl) |
| Flash Point | 447.954°C |
| Water Solubility | 0.2 g/L |
| Solubility | Easily soluble in water and methanol, slightly soluble in ethanol, insoluble in chloroform and ether. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Pale yellow to yellowish brown, crystalline powder |
| Color | Beige to light yellow |
| pKa | pKa 3.27/7.32/9.11(H2O,t =25,I<0.01)(Approximate) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.6500 (estimate) |
| MDL | MFCD00003700 |
| Physical and Chemical Properties | Pale yellow crystalline powder. Melting point 182-182 °c (decomposition). Slightly soluble in ethanol, very slightly soluble in water. Stable in the air, light color fade, easily destroyed in alkaline solution. The formulation adsorbed in calcium carbonate was a yellow-brown dry powder. Hydrochloride yellow crystalline powder, odorless, slightly bitter taste. Melting point of 190-194 ℃, long-term storage at room temperature does not deteriorate, no failure. Soluble in water and methanol, slightly soluble in ethanol, insoluble in chloroform, ether. Its aqueous solution is stable under acidic conditions and unstable under alkaline conditions. |
| Use | Broad-spectrum antibiotics |
Oxytetracycline - Risk and Safety
| Risk Codes | R63 - Possible risk of harm to the unborn child R36 - Irritating to the eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | QI7875000 |
| TSCA | Yes |
| HS Code | 30029090 |
| Toxicity | LD50 oral in rat: 4800mg/kg |
Oxytetracycline - Upstream Downstream Industry
| Raw Materials | Oxalic acid Starch potato Dextrin Calcium carbonate |
| Downstream Products | Oxytetracycline HCL Doxycycline HCl |
Oxytetracycline - Reference
| Reference Show more | 1. Wang Panpan yuan Qixia and Zhou Wenbing. Photocatalytic degradation of tetracycline antibiotics in biogas slurry and reaction kinetics [J]. Journal of Agricultural Engineering 2018 034(023):193-198. 2. Zhang Zheng, Li Pan-jie, Jiang Cai-yun, etc. Investigation of metals and antibiotics in municipal wastewater treatment process [J]. Journal of Nanjing Normal University (Engineering and Technology Edition), 2018, 018(002):86-92. 3. Chi Xiang, Zhou Wenbing, Wu Lin, etc. Oxidation removal of three tetracyclines and three sulfonamides from biogas slurry by Fenton process [J]. Journal of Agricultural Environment Science, 2018, 37(11):100-104. 4. Chi Xiang, Jin Yue, Zhou Wenbing, et al. Oxidation removal of three tetracyclines and three sulfonamides from biogas slurry by ultrasound-Fenton process [J]. Journal of Environmental Sciences, 2019(7). 5. Lu Wang, Xiao-ping si, Hui Tang, et al. Determination of seven antibiotics residues in meat [J]. Analytical Laboratory, 2019, 038(007):854-858. 6. Zeng Hong, Sun Wen Xiao, Deng Yi-hui, Gao Rong, Chen Li, Fang Jun, Liang Yunshan. Screening, identification and characterization of an oxytetracycline-degrading strain [J]. Environmental Science Guide, 2020,39(05):1-6. 7. Tian, Qiaopeng, et al. "Characterization of a robust cold-adapted and thermostable laccase from Pycnoporus sp. SYBC-L10 with a strong ability for the degradation of tetracycline and oxytetracycline by laccase-mediated oxidation." Journal of hazardous mater 8. He, Xiaoyan, et al." A label-free electrochemical DNA biosensor for kanamycin detection based on diblock DNA with poly-cytosine as a high affinity anchor on graphene oxide." Analytical Methods 12.27 (2020): 3462-3469.https://doi.org/10.1039/D0AY00025F 9. [IF=5.833] He Baoshan et al."Voltammetric kanamycin aptasensor based on the use of thionine incorporated into Au@Pt core-shell nanoparticles."Microchim Acta. 2019 Feb;186(2):1-8 10. [IF=2.896] Bao-Shan He et al."Electrochemical aptasensor based on aptamer-complimentary strand conjugate and thionine for sensitive detection of tetracycline with multi-walled carbon nanotubes and gold nanoparticles amplification."Anal Methods-Uk. 2018 Feb;10(7):783 11. [IF=2.329] Wanru Gao et al."Preparation of Magnetic Molecularly Imprinted Polymer (MMIP) Nanoparticles (NPs) for the Selective Extraction of Tetracycline from Milk."Anal Lett. 2020;53(7):1097-1112 12. [IF=2.082] Qin Guo et al."Synergistic inhibition effects of tea polyphenols as adjuvant of oxytetracycline on Vibrio parahaemolyticus and enhancement of Vibriosis resistance of Exopalaemon carinicauda."Aquac Res. 2021 Aug;52(8):3900-3910 13. [IF=7.514] Shuang Han et al."Preparation of mesh covalent organic framework Tppa-2-based adsorption enhanced magnetic molecularly imprinted composite for selective extraction of tetracycline residues from animal-derived foods."Food Chem. 2022 Aug;384:132601 14. [IF=6.498] Jingyun Shi et al."Groundwater antibiotics and microplastics in a drinking-water source area, northern China: Occurrence, spatial distribution, risk assessment, and correlation."Environ Res. 2022 Jul;210:112855 |
Oxytetracycline - Nature
Open Data Verified Data
light yellow crystalline powder. Melting point 181~182 °c (decomposition). Slightly soluble in ethanol, very slightly soluble in water. Stable in the air, light color fade, easily destroyed in alkaline solution. The formulation adsorbed in calcium carbonate was a yellow-brown dry powder.
Last Update：2025-06-10 22:55:16
Oxytetracycline - Preparation Method
Open Data Verified Data
produced by fermentation of Streptomyces lysiticus, calcium carbonate was added to the fermentation broth, filtered, and the solid was dried.
Last Update：2022-01-01 10:10:49
Oxytetracycline - Application
Open Data Verified Data
oxytetracycline is a kind of high quality and high efficiency feed additive for livestock and poultry, which has the function of disease prevention, health care and growth promotion, especially for pigs, chickens and other poultry and large livestock, and no drug residues, non-toxic side effects, do not produce drug resistance. Feed oxytetracycline on Gram-positive bacteria, gram-positive Pneumonia cocci, hemolytic Streptococcus, Staphylococcus aureus, tetanus Bacillus and other parts of the inhibition, high concentrations of bactericidal effect. For Bacterial enteritis, dysentery, leptospirosis, cholera and asthma have obvious effect.
Last Update：2025-08-19 16:24:40
Oxytetracycline - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | oxytetracycline has inhibitory effect on both Gram-positive and gram-negative bacteria, and also acts as a growth promoting agent. For pigs under 2 months of age, the dosage is 15-50g/t; For pigs under 4 months of age, the dosage is 10-20g/t; For chicken feed, the dosage is 5.0-50g/t, the egg production period is disabled, the withdrawal period was 7 days. The antibacterial spectrum and antibacterial principle of oxytetracycline are basically the same as those of tetracycline. Cross resistance of bacteria to tetracycline, oxytetracycline and chlortetracycline. The product of intestinal infection (including amoebic dysentery) efficacy of chlortetracycline and tetracycline slightly better, other indications and tetracycline the same. broad-spectrum antibiotics |
| production method | oxytetracycline is a broad-spectrum antibiotic extracted from a culture solution of Streptomyces Typhimurium. produced by fermentation of Streptomyces rimosus, calcium carbonate is added to the fermentation broth, filtered, and the solid is dried. |
| category | pesticide |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 4800 mg/kg; Oral-mouse LD50: 2240 mg/kg |
| flammability hazard characteristics | combustible, nitrogen oxide emission from fire scene |
| storage and transportation characteristics | warehouse low temperature, ventilation, dry |
| extinguishing agent | water, carbon dioxide, dry powder, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:11
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View History
Oxytetracycline
盐酸克林霉素棕榈酯 USP标准品
小豆蔻(ELETTARIA CARDAMOMUM)籽油
(R)哌嗪(L)酒三石酸盐
3-fluoro-4-chloroaniline
dichloro-aceticacid-anhydride
N-α -Fmoc-D-2,3-diaminopropionic acid hydrochlori
PARA METHOXY PHENYL PIPERAZINE HYDROCHLORIDE
4-C10-13-仲烷基苯磺酸衍生物
盐酸克林霉素棕榈酯 USP标准品
小豆蔻(ELETTARIA CARDAMOMUM)籽油
(R)哌嗪(L)酒三石酸盐
3-fluoro-4-chloroaniline
dichloro-aceticacid-anhydride
N-α -Fmoc-D-2,3-diaminopropionic acid hydrochlori
PARA METHOXY PHENYL PIPERAZINE HYDROCHLORIDE
4-C10-13-仲烷基苯磺酸衍生物
Raw Materials for Oxytetracycline
Downstream Products for Oxytetracycline