NW-1015
2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamide methanesulfonate
CAS: 202825-46-5
Molecular Formula: C17H19FN2O2.CH4O3S
NW-1015 - Names and Identifiers
| Name | 2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamide methanesulfonate |
| Synonyms | NW-1015 NW 1015 FCE-26743 PNU 151774E PNU-151774E FCE-28073(R-isomer) Safinamide mesylate Safinamide mesilate EMD 1195686 Mesylate PNU-151774E,FCE28073 SafinaMide Methanesulfonate (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide N~2~-{4-[(3-fluorobenzyl)oxy]benzyl}-D-alaninamide methanesulfonate 2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamide methanesulfonate (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide methanesulfonate |
| CAS | 202825-46-5 |
| InChI | InChI=1/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m1./s1 |
NW-1015 - Physico-chemical Properties
| Molecular Formula | C17H19FN2O2.CH4O3S |
| Molar Mass | 398.4490232 |
| Melting Point | 210° (dec) |
| Boling Point | 476.7°C at 760 mmHg |
| Specific Rotation(α) | D25 +12.9° (c = 1.1% in 98% acetic acid) |
| Flash Point | 242.1°C |
| Solubility | DMSO 80 mg/mL Water 80 mg/mL Ethanol 13 mg/mL |
| Vapor Presure | 2.98E-09mmHg at 25°C |
| Appearance | powder |
| Color | white to tan |
| Storage Condition | 2-8°C |
| MDL | MFCD15145475 |
| Use | A potent and selective MAO-B inhibitor. |
| In vitro study | Safinamide is a highly selective MAO-B inhibitor with an IC50 of 98 nM in rat brain mitochondria and 9 nM in human brain. Safinamide pair Na Safinamide binds to human MAO B with a Ki of 0.5 μm. Safinamide binds to the human maob in an extended configuration, occupying the Flavin and inlet cavity. |
| In vivo study | Oral administration of Safinamide dose-dependently inhibited mouse brain MAO-B with an IC50 of 0.6 mg/kg, with a rapid recovery of MAO-B activity from the 8th hour onwards. Safinamide significantly inhibited cell body degeneration in the pars compacta of The nigra. Safinamide, administered intraperitoneally 15 minutes before kainic acid administration, prevented the loss of hippocampal neurons and showed neuronal protection at a dose of 10 mg/kg. After 3 hours of intraperitoneal administration of Safinamide at a dose of 100 mg/kg, it showed a neuroprotective effect on hippocampal neurons under ischemic conditions. Safinamide has a high oral bioavailability (80-92%), is rapidly absorbed in plasma, reaches a peak within 0.5-2 hours and then begins to decline, and is highly effective in mice, rats, and monkeys were 3,7, and 13 hours, respectively. |
NW-1015 - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
NW-1015 - Introduction
Safinamide Mesylate is a Safinamide methanesulfonate, which is a selective and reversible MAO-B inhibitor with IC50 of 98 nM, which is 5918 times more selective than acting on MAO-A.
Last Update：2022-10-16 17:14:49
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