NSC-213841
U-104
CAS: 178606-66-1
Molecular Formula: C13H12FN3O3S
NSC-213841 - Names and Identifiers
| Name | U-104 |
| Synonyms | U104 U 104 U-104 MST-104 CS-1653 MST-104 NSC 213841 NSC-213841 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]benzenesulfonamide |
| CAS | 178606-66-1 |
NSC-213841 - Physico-chemical Properties
| Molecular Formula | C13H12FN3O3S |
| Molar Mass | 309.32 |
| Density | 1.523±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 242-243℃ |
| Solubility | DMSO: >15mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 9.94±0.12(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | 4T1 cells under hypoxic conditions U-104 (50 μm) blocks the mesenchymal phenotype of the cancer stem cell population. U-104 (<50 μm) significantly reduced the migration of the metastatic MDA-MB-231 LM2-4Luc cells with a dose-dependent profile, while the cells grew into compact clones similar to the parental MDA-MB-231 cells. U-104 has an aromatic group at the second nitrogen urea group. 4T1 cells under hypoxic conditions U-104 (50 μm) blocked the mesenchymal phenotype of the cancer stem cell population. U-104 (<50 μm) significantly reduced metastases by MDA-MB-231 to LM2-4Luc. U-104 has an aromatic group at the second nitrogen urea group. |
| In vivo study | U-104 (38 mg/kg) inhibited the growth of primary tumors in mice implanted with MDA-MB-231 LM2-4Luc cells. U-104 (19 mg/kg) inhibited metastasis formation in the 4T1 experiment using a metastasis mouse model. In the NOD/SCID mouse model implanted with MDA-MB-231 LM2-4Luc cells, U-104 (38 mg/kg) significantly slowed primary tumor growth and reduced cancer stem cell numbers. U-104(5 mg/mL, fed) treatment significantly delayed the growth rate of tumor in Balb/c mice implanted with 4T1 cells. U-104 (38 mg/kg) inhibited implantation by MDA-MB-231 LM2-4. In implantation MDA-MB-231 LM2-4Luc. |
NSC-213841 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
NSC-213841 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.233 ml | 16.164 ml | 32.329 ml |
| 5 mM | 0.647 ml | 3.233 ml | 6.466 ml |
| 10 mM | 0.323 ml | 1.616 ml | 3.233 ml |
| 5 mM | 0.065 ml | 0.323 ml | 0.647 ml |
Last Update：2024-01-02 23:10:35
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