ME0328
ME0328
CAS: 1445251-22-8
Molecular Formula: C19H19N3O2
ME0328 - Names and Identifiers
ME0328 - Physico-chemical Properties
| Molecular Formula | C19H19N3O2 |
| Molar Mass | 321.37 |
| Solubility | DMSO: soluble10mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| In vitro study | ME0328 is soluble, cell permeable, and metabolically stable in human liver microsomes and rat hepatocytes. In A549 and MRC5 cells, ME0328 (10 μm) significantly delayed the γH2AX site by affecting ARTD3 without significant toxicity. |
ME0328 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
ME0328 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.112 ml | 15.558 ml | 31.117 ml |
| 5 mM | 0.622 ml | 3.112 ml | 6.223 ml |
| 10 mM | 0.311 ml | 1.556 ml | 3.112 ml |
| 5 mM | 0.062 ml | 0.311 ml | 0.622 ml |
Last Update：2024-01-02 23:10:35
ME0328 - Reference Information
| biological activity | ME0328 is a potent selective PARP inhibitor with an IC50 of 0.89 μM, and its selectivity to PARP3 is about seven times higher than that to PARP1. |
| In vitro studies | ME0328 is soluble, permeable cells, and metabolically stable in human liver microsomes and rat liver cells. In A549 and MRC5 cells, ME0328 (10 μM) significantly delayed the γH2AX site by affecting ARTD3 without significant toxicity. |
| target | ARTD3/PARP3 0.89 μ m (IC 50 ) ARTD1/PARP1 6.3 μ m (IC 50 ) ARTD2/PARP2 10.8 μ m (IC 50 ) ARTD6/TNKS2 34.3 μ m (IC 50 ) ARTD5/TNKS1 47.3 μ m (IC 50 ) ARTD10/PARP10 71.3 μ m (IC 50 ) |
Last Update：2024-04-09 20:52:54
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Featured ProductsSpot supply
Product Name: ME0328 Visit Supplier Webpage Request for quotationCAS: 1445251-22-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: ME0328 Request for quotationCAS: 1445251-22-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: ME0328 Visit Supplier Webpage Request for quotationCAS: 1445251-22-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: ME0328 Visit Supplier Webpage Request for quotationCAS: 1445251-22-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: ME0328 Visit Supplier Webpage Request for quotationCAS: 1445251-22-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
ME0328
AMMONIUM BENZOATE EXTRA PURE 1 KG
HS1371
ZS
blue base nb
Blue LDS
Chloramine-T
Gluconic acid sodium salt
Dimethylthiophosphoryl chloride
3-CHLOROANISOLE
AMMONIUM BENZOATE EXTRA PURE 1 KG
HS1371
ZS
blue base nb
Blue LDS
Chloramine-T
Gluconic acid sodium salt
Dimethylthiophosphoryl chloride
3-CHLOROANISOLE