LEA-103
Ropivacaine hydrochloride hydrate
CAS: 132112-35-7
Molecular Formula: C17H26N2O.ClH.H2O
LEA-103 - Names and Identifiers
LEA-103 - Physico-chemical Properties
| Molecular Formula | C17H26N2O.ClH.H2O |
| Molar Mass | 328.88 |
| Melting Point | 267-269°C |
| Boling Point | 495.9°C at 760 mmHg |
| Specific Rotation(α) | D20 -7.28° (c = 2 in water) |
| Flash Point | 253.7°C |
| Solubility | H2O: soluble5mg/mL, clear |
| Vapor Presure | 1.18E-10mmHg at 25°C |
| Appearance | powder |
| Color | white to off-white |
| Storage Condition | 2-8°C |
| In vitro study | Rpivacaine HCl is a local anesthetic. Rpivacaine HCl induces nerve block by reversibly inhibiting sodium ion flow in nerve fibers. The pKa of Ropivacaine HCl is ~ 8.2. Rpivacaine HCl has the potential to induce cardiovascular toxicity and CNS toxicity at high plasma concentrations. |
LEA-103 - Risk and Safety
| Risk Codes | R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R41 - Risk of serious damage to eyes |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933399090 |
LEA-103 - Reference Information
| Overview | ropivacaine hydrochloride is an amide long-acting local anesthetic. Its fat-soluble than lidocaine, less than bupivacaine, the intensity of anesthesia for procaine 8 times. Because the products of its metabolism in the liver also have local anesthetic effect, the effect is more lasting. Mainly used for regional block anesthesia and epidural anesthesia, for postoperative and labor analgesia. |
| Use | ropivacaine hydrochloride is suitable for surgical anesthesia -epidural anesthesia, including cesarean section -- subarachnoid anesthesia -- regional block Acute Pain Control -- continuous epidural infusion or intermittent single medication, if postoperative or vaginal labor analgesia -regional block |
| biological activity | Ropivacaine HCl (LEA-103) is an anesthetic, block Impulse of the conduction on the nerve fibers by reversibly inhibiting the influx of sodium ions. |
| Target | IC50: sodium ion influenza IC50: 402.7 μm (TREK-1 in COS-7 cell's membrane) |
| Animal Model: | Adult Sprague-Dawley rats (300–400g) |
| Dosage: | 1 μM |
| Administration: | Infusion (added to the perfusate reservoir) |
| Result: | Attenuated pressure-dependent increases in filtration coefficient (K f ). |
Last Update：2024-04-09 21:21:28
Supplier List
Spot supply
Product Name: (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride hydrate Request for quotationCAS: 132112-35-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Ropivacaine hydrochloride Visit Supplier Webpage Request for quotationCAS: 132112-35-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Ropivacaine hydrochloride Visit Supplier Webpage Request for quotationCAS: 132112-35-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Ropivacaine HCl Visit Supplier Webpage Request for quotationCAS: 132112-35-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride hydrate Request for quotationCAS: 132112-35-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Ropivacaine hydrochloride Visit Supplier Webpage Request for quotationCAS: 132112-35-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Ropivacaine hydrochloride Visit Supplier Webpage Request for quotationCAS: 132112-35-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Ropivacaine HCl Visit Supplier Webpage Request for quotationCAS: 132112-35-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
View History