L-甲基多巴
alpha-Methyldopa sesquihydrate
CAS: 41372-08-1
Molecular Formula: C10H13NO4·1·5H2O
L-甲基多巴 - Names and Identifiers
| Name | alpha-Methyldopa sesquihydrate |
| Synonyms | DISCONTINUED alpha-Methyldopa sesquihydrate (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate |
| CAS | 41372-08-1 |
| EINECS | 609-918-1 |
L-甲基多巴 - Physico-chemical Properties
| Molecular Formula | C10H13NO4·1·5H2O |
| Molar Mass | 238.24 |
| Melting Point | >300 °C(lit.) |
| Water Solubility | 0.1-1 g/100 mL at 23 ºC |
| Appearance | Shape neat, color White to Off-White |
| Storage Condition | 2-8°C |
| Stability | Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere. |
| Physical and Chemical Properties | Bioactive Methyldopa hydrate (L-(-)-α-Methyldopa hydrate) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a prodrug that is metabolized in the central nervous system (α-Methyllepinephrine). |
| Use | Use L-Methyldopa is a beta-blocker cardiovascular drug that has a good effect on moderate-procedure primary and renal hypertension. |
L-甲基多巴 - Risk and Safety
| Risk Codes | R20/21 - Harmful by inhalation and in contact with skin. R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R65 - Harmful: May cause lung damage if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | YP2860000 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 2922504500 |
L-甲基多巴 - Improved Synthesis of L-methyldopa
from Wanfang
Author:
Wu Fan macro , tiny flowers , Yang Xueyan , shuhaiying , Zhou Weiguo
Abstract:
(3 ',4'-dimethoxyphenyl)-2-amino-2-methylpropionitrile was obtained from 3, 4-dimethoxyphenylacetone by Strecker reaction, L-(3 ',4'-dimethoxyphenyl)-2-amino-2-methylpropionitrile hydrochloride is then resolved with L-tartaric acid and hydrolyzed, demethylation gave the target product L-methyldopa in 50.4% yield.
Key words:
L-methyldopa 3, 4-dimethoxyphenylacetone Strecker reaction
DOI:
10.3969/j.issn.1001-9677.2008.02.015
cited:
year:
2008
Last Update：2024-01-02 23:10:35
L-甲基多巴 - Preparation of L-methyl Methyl gallate
from Palm Bridge research
patent type:
invention patent
Application (patent) number:
CN201711461044.4
application date:
20171228
Public/Announcement Number:
CN108147974A
Public/announcement date:
20180612
applicant (patent):
Shandong Xinhua Pharmaceutical Co., Ltd.
inventor:
Wang Bing , Shen Ping , Yan Pei , Wang Yiyun , hole Blue , fan Chunwei , Wang Xichun , Wang Zhi
National and provincial code:
CN370303
Abstract:
The invention relates to a preparation process of L-methyl methanone, belonging to the field of organic chemical synthesis. The preparation process of L methyl methyl methyl ester comprises the following steps: 1. L methyl DOPA and methanol were added sequentially, and hydrogen chloride gas was introduced; 2. The esterification reaction took place at 045 °c for 1072 hours; 3. After completion of the esterification reaction, the product was obtained by filtration, dissolution, neutralization, crystallization, centrifugation and drying. The preparation process of the invention can improve the yield and reduce the energy consumption, and at the same time, the mother liquor can be recycled, the cost is reduced, and the environment is friendly.
Last Update：2023-08-16 22:09:08
L-甲基多巴 - Spectroscopic data and structural confirmation of L-methyldopa
from hownet
Author:
Abstract:
Objective to confirm the structure of L-methyldopa. Methods ultraviolet, infrared, hydrogen spectrum, carbon spectrum and mass spectrum were used to analyze the structure. Results The maximum absorption peak was red-shifted in 0.1mol · L-1 sodium hydroxide solution. The infrared spectrum showed that the molecule contained hydroxyl, Amino, carbonyl and benzene ring; the molecular ion peak m/z of the mass spectrum was 211. Conclusion The structure of L-methyldopa can be confirmed by the above method.Key words:
L-methyldopa Structure corroboration
DOI:
CNKI:SUN:XDYD.0.2009-S1-015
year:
2009
Last Update：2023-08-16 22:09:08
Supplier List
Featured ProductsSpot supply
Product Name: Methyldopa hydrate Visit Supplier Webpage Request for quotationCAS: 41372-08-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoicacidsesquihydrate Request for quotationCAS: 41372-08-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 3-(3,4-DIHYDROXYPHENYL)-2-METHYL- Visit Supplier Webpage Request for quotationCAS: 41372-08-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Methyldopa hydrate (Standard) Visit Supplier Webpage Request for quotationCAS: 41372-08-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: alpha-Methyldopa sesquihydrate Visit Supplier Webpage Request for quotationCAS: 41372-08-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: alpha-Methyldopa sesquihydrate Request for quotation
CAS: 41372-08-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 41372-08-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: α-Methyl-L-DOPA Visit Supplier Webpage Request for quotation
CAS: 41372-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 41372-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Methyldopa hydrate Visit Supplier Webpage Request for quotationCAS: 41372-08-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoicacidsesquihydrate Request for quotationCAS: 41372-08-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 3-(3,4-DIHYDROXYPHENYL)-2-METHYL- Visit Supplier Webpage Request for quotationCAS: 41372-08-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Methyldopa hydrate (Standard) Visit Supplier Webpage Request for quotationCAS: 41372-08-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: alpha-Methyldopa sesquihydrate Visit Supplier Webpage Request for quotationCAS: 41372-08-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: alpha-Methyldopa sesquihydrate Request for quotation
CAS: 41372-08-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 41372-08-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: α-Methyl-L-DOPA Visit Supplier Webpage Request for quotation
CAS: 41372-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 41372-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History