Molecular Formula | C16H10F8N4O |
Molar Mass | 426.26 |
Density | 1.56±0.1 g/cm3(Predicted) |
Boling Point | 477.2±55.0 °C(Predicted) |
pKa | 0.59±0.50(Predicted) |
Storage Condition | -20℃ |
In vitro study | In MCL cells, KPT-276 resulted in significant growth inhibition and induction of apoptosis. KPT-276 specifically irreversibly inhibits the nuclear export function of XPO1 and reduces the activity of 12 HMCLs. In primary MM patient samples, KPT-276 were also effective in inducing apoptosis. |
In vivo study | In a xenograft AML mouse model, KPT-276 significantly prolonged survival and reduced leukemia burden in leukemic mice. In a severe combined immunodeficient mouse model with MCL, tumor growth was significantly inhibited by KPT-276 with no severe toxicities. In the Vk * MYC transgenic MM mouse model, KPT-276 reduced the spike of the monoclonal antibody, and in the xenograft MM mouse model, KPT-276 inhibited tumor growth. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.346 ml | 11.73 ml | 23.46 ml |
5 mM | 0.469 ml | 2.346 ml | 4.692 ml |
10 mM | 0.235 ml | 1.173 ml | 2.346 ml |
5 mM | 0.047 ml | 0.235 ml | 0.469 ml |