KEA1-97
KEA1-97
CAS: 2138882-71-8
Molecular Formula: C15H9Cl2FN4
KEA1-97 - Names and Identifiers
| Name | KEA1-97 |
| Synonyms | KEA1-97 1,3,5-Triazin-2-amine, 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)- |
| CAS | 2138882-71-8 |
KEA1-97 - Physico-chemical Properties
| Molecular Formula | C15H9Cl2FN4 |
| Molar Mass | 335.16 |
| Density | 1.466±0.06 g/cm3(Predicted) |
| Boling Point | 530.3±52.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 0.57±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | KEA1-97 is a thioredoxin-caspase 3 interaction disruptor. It has been shown to impair breast cancer pathogenicity. KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity. Moreover, KEA1-97 impairs in vivo breast tumor xenograft growth. |
KEA1-97 - Reference
| Reference Show more | 1: Anderson KE, To M, Olzmann JA, Nomura DK. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017 Oct 20;12(10):2522-2528. doi: 10.1021/acschembio.7b00711. Epub 2017 Sep 13. PubMed PMID: 28892616. |
KEA1-97 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
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