KAHWEOL
Kahweol
CAS: 6894-43-5
Molecular Formula: C20H26O3
KAHWEOL - Names and Identifiers
KAHWEOL - Physico-chemical Properties
| Molecular Formula | C20H26O3 |
| Molar Mass | 314.42 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Melting Point | 88-90℃ |
| Boling Point | 476.6±45.0 °C(Predicted) |
| Appearance | White solid |
| pKa | 14.43±0.40(Predicted) |
| Storage Condition | −20°C |
| In vitro study | Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells. Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells. Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only. kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells. kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism. Western Blot Analysis Cell Line: 3T3-L1 cells Concentration: 0, 5, 10, 25 μg/ml Incubation Time: Result: Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner. |
KAHWEOL - Reference Information
| Effect | Coffee bean alcohol and coffee alcohol (K-C) have potential effects on carcinogen-activated hepatocyte pigment P450 enzyme (CYP450) and sulfur transferase (S ULT). |
| The application of | K-C has an inhibitory effect on CYP450 rather than a complete inhibitory effect. K-C inhibition of CYP450 and S ULT may weaken the activation of carcinogens and play a role in chemical cancer prevention. The complex mixture and its purified monomer components caffein alcohol and caffeanol will show significantly different effects in terms of activity. |
| biological activity | Kahweol is one of the components of coffee Coffea Arabica and has anti-inflammatory, anti-angiogenic and anti-cancer activities. Kahweol adipogenesis of lipogenesis inhibited by activation of kinase (AMPK) and increased glucose uptake. Kahweol induces apoptosis (apoptosis). |
| target | AMPK; adipogenesis; apoptosis |
| in vitro study | Kahweol (20-40μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells. Kahweol (20-40μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells. Kahweol (20-40μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only. kahweol (0-25μ g/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent in 3T3-L1 cells. kahweol (0-25μ g/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism. Western Blot Analysis Cell Line: 3T3-L1 cells Concentration: 0,5, 10, 25 μg/ml Incubation Time: Result: Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner. |
| Cell Line: | 3T3-L1 cells |
| Concentration: | 0, 5, 10, 25 μg/ml |
| Incubation Time: | |
| Result: | Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner. |
Last Update：2024-04-09 21:54:55
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