K145
K145
CAS: 1309444-75-4
Molecular Formula: C18H24N2O3S
K145 - Names and Identifiers
| Name | K145 |
| Synonyms | K145 3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione 2,4-Thiazolidinedione, 3-(2-aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]- |
| CAS | 1309444-75-4 |
K145 - Physico-chemical Properties
| Molecular Formula | C18H24N2O3S |
| Molar Mass | 348.46 |
| Solubility | 10 mM in DMSO |
| Storage Condition | -20℃ |
K145 - References
| biological activity | K145 is a selective, substrate-competitive and orally active SphK2 inhibitor, IC50 was 4.3 μm and Ki was 6.4 μm. K145 had no activity on SphK1 and other protein kinases. K145 can induce apoptosis and has strong anti-tumor activity. |
| Target | IC50: 4.3 µm (SphK2) Ki: 6.4 µm (SphK2) |
| Cell Line: | U937 cells U937 cells U937 cells |
| Concentration: | 0 µM, 4 µM, 6 µM, 8 µM, 10 µM 10 µM 4 µM, 8 µM |
| Incubation Time: | 24 hours, 48 hours, 72 hours 24 hours 3 hours |
| Result: | Significantly inhibited the growth of U937 cells in a concentration-dependent manner. Significantly induced apoptosis in U937 cells. Phosphorylated ERK and Akt were decreased. Oral gavage; daily; for 15 daysInhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed. |
| Animal Model: | BALB/c-nu mice injected with U937 cells |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: 3-(2-Aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione Request for quotationCAS: 1309444-75-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: K145 Visit Supplier Webpage Request for quotationCAS: 1309444-75-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: K145 Visit Supplier Webpage Request for quotationCAS: 1309444-75-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: K145 Visit Supplier Webpage Request for quotation
CAS: 1309444-75-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1309444-75-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: 3-(2-Aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione Request for quotationCAS: 1309444-75-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: K145 Visit Supplier Webpage Request for quotationCAS: 1309444-75-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: K145 Visit Supplier Webpage Request for quotationCAS: 1309444-75-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: K145 Visit Supplier Webpage Request for quotation
CAS: 1309444-75-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1309444-75-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
K145
52012-29-0
Phosphocholine
BEVANTOLOL HCL
STO-609 free base
HSPyU
Ammonium iodide
63-91-2
ethane,refrigeratedliquid
(R)-3-(1-Methylethyl)morpholine
52012-29-0
Phosphocholine
BEVANTOLOL HCL
STO-609 free base
HSPyU
Ammonium iodide
63-91-2
ethane,refrigeratedliquid
(R)-3-(1-Methylethyl)morpholine