IY5511
Radotinib(IY-5511)
CAS: 926037-48-1
Molecular Formula: C27H21F3N8O
IY5511 - Names and Identifiers
| Name | Radotinib(IY-5511) |
| Synonyms | IY5511 Supect CS-1712 Radotinib RADOTINIB IY5511 HCl. IY5511 HCL. Radotinib HCl Radotinib(IY-5511) |
| CAS | 926037-48-1 |
IY5511 - Physico-chemical Properties
| Molecular Formula | C27H21F3N8O |
| Molar Mass | 530.5 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| pKa | 12.94±0.70(Predicted) |
| Storage Condition | -20℃ |
| Use | Radotinib, and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of Y, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) with resistance or intolerance of other tyrosine kinase Bcr-Abl inhibitors。 |
| In vitro study | In vitro, Radotinib binds to BCR-ABL1 and reduces the phosphorylation of a target protein, CrkL, by BCR-ABL1. Radotinib also effectively inhibited the proliferation of BCR-ABL1 of the normal mutant clone beads without affecting T315I. In AML cells, radotinib significantly reduces cell viability, promotes differentiation, and induces CD11b expression and apoptosis. radotinib also Induced CD11b expression and decreased activity in NB4,THP-1, and Kasumi-1 cells. |
IY5511 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.885 ml | 9.425 ml | 18.85 ml |
| 5 mM | 0.377 ml | 1.885 ml | 3.77 ml |
| 10 mM | 0.189 ml | 0.943 ml | 1.885 ml |
| 5 mM | 0.038 ml | 0.189 ml | 0.377 ml |
Last Update：2024-01-02 23:10:35
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View History
IY5511
4-chlorophenylhydrazine hcl
polyethylene glycol dimesylate
4729-05-9
14040-75-6
抗旋定
Ethacrynic acid
80690-07-9
MEG SODIUM SUCCINATE
4-chlorophenylhydrazine hcl
polyethylene glycol dimesylate
4729-05-9
14040-75-6
抗旋定
Ethacrynic acid
80690-07-9
MEG SODIUM SUCCINATE