Harpagide
Harpagide
CAS: 6926-08-5
Molecular Formula: C15H24O10
Harpagide - Names and Identifiers
Harpagide - Physico-chemical Properties
| Molecular Formula | C15H24O10 |
| Molar Mass | 364.35 |
| Density | 1.66±0.1 g/cm3(Predicted) |
| Boling Point | 637.1±55.0 °C(Predicted) |
| Flash Point | 339.107°C |
| Solubility | Soluble in methanol and water |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White needle crystal |
| pKa | 12.10±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.663 |
| MDL | MFCD03267740 |
| Physical and Chemical Properties | White needle-like crystals, easily soluble in methanol and water, derived from Scrophulariae. |
| In vitro study | Harpagide shows cytotoxic activity over 50% in a concentration of 90 μg/mL, Harpagide on the A431 and HeLa cell lines. The cytotoxic effect of Harpagide on the MCF7 cell line in a concentration of 90 μg/mL. |
Harpagide - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
Harpagide - Reference
| Reference Show more | 1. Li Li, Zhou, Jiang, Yuan, Zhi, Ying, et al. Effects of different planting patterns on yield and quality of Scrophularia [J]. Shi Zhen, National Medicine 2020 v.31;No.293(01):195-197. 2. Shen zhanyun, Zhu Bo, Zhang Quan-long, et al. Isolation and identification of endophytic fungi from habaoside and habaoside-producing radix scrophulariae [J]. Chinese Journal of Traditional Chinese Medicine, 2019 v.44(10):88-92. 3. Li Li, Zhou, Jiang, Yuan, Zhi, Ying, et al. Determination of five index components in radix scrophulariae by dispersive solid phase extraction and HPLC [J]. Strait pharmacy 2019 031(011):30-33. 4. Liu Fang, Zhou Xiaojiang, Yuan Zhiying, etc. Study on the grade quality of radix scrophulariae based on fingerprint combined with multi-index determination [J]. Chinese herbal medicine, 2019, 50(05):1238-1243. 5. Zhou Binwen, Zhong Xiaoming, Huang Zhen. Optimization of heat reflux extraction of iridoid glycoside from radix scrophulariae [J]. Chinese traditional medicines, 2018, 040(006):1292-1297. 6. Liu Fang, Huang Xiaojie, Lin Meilan, etc. Study on the grade quality of radix scrophulariae [J]. New drugs of traditional Chinese medicine and clinical pharmacology, Volume 31, 20208, pages 978-983, ISTIC PKU CSCD CA, 2020. 7. He Shiru, Li Li, Xu Guang Ming, etc. Rapid determination of effective components in radix scrophulariae by solid phase extraction and high performance liquid chromatography [J]. Asia-Pacific traditional medicine, 2020, 016(001):54-57. 8. [IF = 6.799] Yun Tang et al."Quantum oriented regeneration of charged neurons by natural product concentration gradients in a 3D microfluidic device." Lab Chip. 2018 Mar;18(6):971-978 9. [IF = 1.902] Yukun Feng et al."Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma: application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction."Biomed Chromatog 10. [IF=2.63] Sun Ke-han et al."Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong'an Decoction."Evidence-based Complementary and Alternative Medicine. 2022;2022:4604601 |
Harpagide - Reference Information
| Effect | Haba glycoside is one of the main iridoid glycosides of Scrophulariae. A large number of studies have shown that the pharmacological activity of haberoside is related to the traditional efficacy of Scrophulariae. Haberoside can promote the proliferation of spleen lymphocytes-Concanavalin A induced, and has neuroprotective effect and inhibition of platelet aggregation. |
| biological activity | Harpagide is a kind of iris glycoside isolated from Scrophularia cryptophila. it has antiparasitic activity and good in vitro trypanosome insecticidal activity to T. B. rhodesiense, IC50 is 21 μg/mL,Harpagide IC50 to L. donovani is 2.0 μg/mL. Harpagide also has important anti-inflammatory activity. |
| in vitro study | Harpagide shows cytotoxic activity over 50% in a concentration of 90 μg/mL, Harpagide on the A431 and HeLa cell lines. The cytotoxic effect of Harpagide on the MCF7 cell line in a concentration of 90 μg/mL. |
| Chemical properties | White needle-like crystals, easily soluble in methanol and water, derived from Scrophulariae. |
| use | habaroside has antibacterial; Antipyretic; Increase myocardial nutritional blood flow, improve hypoxia tolerance, protect vascular endothelial cells, etc. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: antibacterial; antipyretic; increase myocardial nutritional blood flow, improve hypoxia tolerance, etc. |
Last Update：2024-04-09 02:00:01
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