HOS
Hydroxylamine-O-sulfonic acid
CAS: 2950-43-8
Molecular Formula: H3NO4S
HOS - Names and Identifiers
| Name | Hydroxylamine-O-sulfonic acid |
| Synonyms | HOS haos 2950-43-8 sulfoperamidicacid permonosulfamicacid amidosulfonicperacid aminomonopersulfuricacid amidoperoxymonosulfuricacid o-hydroxylammoniumsulfonate Hydroxylamine-O-sulfonicacid Hydroxylamine-O-sulfonic acid (Aminooxy)(hydroxy)sulfan-dioxid (aminooxy)(hydroxy)sulfane dioxide (Aminooxy)(hydroxy)sulfane-dioxyde sulfane, (aminooxy)hydroxy-, dioxide |
| CAS | 2950-43-8 |
| EINECS | 220-971-6 |
| InChI | InChI=1/H3NO4S/c1-5-6(2,3)4/h1H2,(H,2,3,4) |
| InChIKey | DQPBABKTKYNPMH-UHFFFAOYSA-N |
HOS - Physico-chemical Properties
| Molecular Formula | H3NO4S |
| Molar Mass | 113.09 |
| Density | 2.2 g/cm3 (20℃) |
| Melting Point | 210°C (dec.)(lit.) |
| Boling Point | 39 °C(Press: 0.4 Torr) |
| Water Solubility | soluble |
| Solubility | 675g/l (slow decomposition) |
| Vapor Presure | 0-53.329Pa at 25-39℃ |
| Appearance | Crystalline Powder |
| Color | White |
| BRN | 956566 |
| pKa | -6.47±0.18(Predicted) |
| PH | 0.8 (100g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Hygroscopic |
| Refractive Index | 1.534 |
| Physical and Chemical Properties | White solid crystalline powder, soluble in water, easy to absorb moisture, should be sealed and dry place for storage, this product is a solid corrosion product, should avoid contact with oxidants, acidic oxides, strong bases, acid anhydride. Hydroxylamine-O-sulfonic acid is widely used in the synthesis of pharmaceuticals, pesticides, dyes and so on. |
HOS - Risk and Safety
| Risk Codes | R34 - Causes burns R50 - Very Toxic to aquatic organisms R43 - May cause sensitization by skin contact R40 - Limited evidence of a carcinogenic effect R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - S27 - Take off immediately all contaminated clothing. S22 - Do not breathe dust. |
| UN IDs | UN 3260 8/PG 3 |
| WGK Germany | 3 |
| RTECS | NC5427000 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | Y |
| HS Code | 28111980 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
| Packing Group | III |
HOS - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Introduction | Hydroxylamine-O-sulfonic acid is an important reagent for the synthesis of dyes, medicines, and pesticide intermediates, and it is also a catalyst in the polymerization reaction. This reagent can directly introduce amino groups on carbon atoms, nitrogen atoms, sulfur atoms and phosphorus atoms, but it is not only an amination reagent, but also a denitrizing reagent, it has a wide range of uses in industry. |
| application | hydroxylamine-O-sulfonic acid (HOSA)NH_2OSO_3H, because the nitrogen atom in the molecule is both electrophilic and nucleophilic, it is a very important reagent in organic synthesis. It is a good reagent for the synthesis of dyes, pharmaceutical and pesticide intermediates, and a catalyst in polymerization reactions. It has a wide range of uses in industry. |
| preparation | 63ml of 20 ~ 25% fuming sulfuric acid is slowly added to 16.4g of hydroxylamine sulfate under mechanical stirring. The temperature is controlled below 60°C, and the dropping time is 40~60 minutes. After dropping, the temperature rises to 60°C, and then continue stirring for 2-3 hours. Cold to 10°C and stir for 1 hour, then drip in 100ml of ethyl acetate. Let the thick liquid stand for half an hour, separate and filter quickly. The crude product was washed with ethyl acetate and dried in vacuum to obtain 21.5g of hydroxylamine-O-sulfonic acid (yield 95%). The product is stored on P2O6 in a vacuum dryer. The purity of the product is 87. 69%. |
| production method | 1. put 225 grams of 30% fuming sulfuric acid in a dry 500 ml hard glass three-necked round bottom flask. Install mercury seal agitator at bottle mouth. Thermometer and outlet branch connected to calcium chloride drying tower. The thermometer is inserted into the liquid to make the liquid level slightly higher than the mercury bulb. Dry 62g (0.37 mol) with stirring. The giant fine di (amines) sulfate is slowly added in small parts to prevent agglomeration on the bottle wall. With the addition of antelope amine salt, significant overflow increased (up to 100 ℃). After the solids are added, continue stirring at room temperature for 1 hour, and then place the flask in an ice bath to cool 0°C. 150 ml of anhydrous diethyl ether frozen in an ice bath for 1 hour in advance is added to the reaction mixture through a dropping funnel. At this time, the temperature will rise. The reaction mixture must be stirred and cooled, and the adding speed is controlled so that the temperature does not exceed 50 ℃. After the resulting white suspension is cooled to about 15 degrees C, it is filtered with a glass core funnel of medium porosity to separate most of the mother liquor, but leaves part of the mother liquor in sufficient amount to maintain solid moisture. Then wash the moist solid 7 times with 110 ml of cold anhydrous ether each time, and pay attention not to drain the ether on the solid between each washing. Suction must be stopped each time, and the ether and solid must be agitated violently to remove all traces of sulfuric acid. After washing, the product is dried for 5 minutes, and then dried in vacuum for 12 to 14 hours to obtain 83 to 85 grams (98 to 99%). Store in a vacuum dryer containing concentrated sulfuric acid. |
Last Update：2024-04-09 21:11:58
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