Guanidinebase
guanidine
CAS: 113-00-8
Molecular Formula: CH5N3
Guanidinebase - Names and Identifiers
| Name | guanidine |
| Synonyms | imidourea guanidine Carbamidine Guanidinebase carbamamidine Diaminomethanimine Ribavirin Impurity T Guanidine, free base |
| CAS | 113-00-8 |
Guanidinebase - Physico-chemical Properties
| Molecular Formula | CH5N3 |
| Molar Mass | 59.07 |
| Density | 1.6000 (rough estimate) |
| Melting Point | ~50° |
| Boling Point | 82.3°C (rough estimate) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.595 |
| Physical and Chemical Properties | Chemical properties of colorless crystals. The melting point was about 50 °c. Very soluble in water and alcohol. Deliquescence, easy to absorb carbon dioxide from the air, a strong alkaline. It was decomposed into melamine and ammonia when heated to 160 °c. |
| Use | Uses as an intermediate in organic synthesis. Mainly used in the manufacture of sulfonamide drugs and dyes. Since the free guanidine is difficult to separate, its salts such as guanidine hydrochloride, guanidine nitrate, guanidine carbonate, guanidine sulfate and the like are common commercial products. |
Guanidinebase - Risk and Safety
| UN IDs | 1759 |
Guanidinebase - A method for the determination of known impurities in ribavirin preparations
from Baidu library
Application (Patent) No.:
CN201410514139.8
date of application:
2014-09-29
public/announcement number:
CN105445387A
date of publication/announcement:
2016.03.30
Applicant (patentee):
Shanghai Xinyi Pharmaceutical Co., Ltd.
Inventor:
Jing Zhixin ,< a href = "https://xueshu.baidu.com/s?wd=author: (Shao Qi) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Shao Qi ,< a href = "https://xueshu.baidu.com/s?wd=author: (Wang Minjuan) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Wang Minjuan , Sun Ningyun , Zhang Jundong
national and provincial code:
CN310115
Summary:
the invention discloses a detection method for determining known impurities in ribavirin preparations, the steps of which are as follows: preparing a test solution for ribavirin preparations according to a conventional method in the art, and then determining the content of one or more of known impurities A,B,C,D,F and G by high performance liquid chromatography; The chromatographic conditions are as follows: the eluent is composed of mobile phase A and mobile phase B, and mobile phase A is, mobile phase B consists of solution C with a volume ratio of 96:4-94:6 and acetonitrile. Solution C is prepared by the following method: 1g of sodium sulfate and 950mL of water are uniformly mixed in an amount of 1000mL, pH value is adjusted to 2.7-2.9 with phosphoric acid solution, diluted to 1000mL, mixed evenly and filtered to obtain. The detection method is simple to operate, good peak shape, high sensitivity, low detection limit, high precision, good reproducibility, and can accurately, stably and efficiently determine the known impurities in ribavirin preparations, which can be used by pharmaceutical companies Daily production use.
Last Update：2024-01-02 23:10:35
Guanidinebase - Determination of Related Substances in Ribavirin Eye Drops by High Performance Liquid Chromatography
From VIP Journal Professional Edition
Author:
Summary:
objective to establish an HPLC method for the determination of related substances in ribavirin eye drops. Methods Waters Atlantis T3(250mm × 4.6mm,5 μm), 0.1% sodium sulfate aqueous solution (pH = 2.8) as mobile phase A, acetonitrile-mobile phase A(5:95) as mobile phase B, 20% acetonitrile as mobile phase C, acetonitrile as mobile phase D, gradient elution, flow rate 1.0 mL min (-1), column temperature 30 ℃, the detection wavelength is 220 nm. Results The recovery rate of impurity A was 94.6% ~ 100.3%(n = 3), and the correction factor was 2.0. The unknown impurity was identified as 2-sulfobenzoic acid. Conclusion The method is specific, simple and reliable. It is suitable for the examination of related substances in ribavirin eye drops and can provide reference for its quality control.
keywords:
ribavirin eye drops related substances high performance liquid chromatography 2-sulfobenzoic acid
Year:
2021
Last Update：2023-08-16 22:23:51
Guanidinebase - Determination of the uncertainty of ribavirin in veterinary powder by high performance liquid phase method
From Wanfang
Author:
Lin Haidan ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(ec61af17132307b6) author:(Yu Xiao)" target = "_blank"> Yu Xiao ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(ffc784ccd6fb347d) author:(Deng Guodong)" target = "_blank"> Deng Guodong/a >,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(f1469473d6a3393b) author:(Cui Chengfu)" target = "_blank"> Cui Chengfu ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(56 a9f102246af510) author:(Peng Xinyu)" target = "_blank"> Peng Xinyu ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(4 f23feb524051506) author:(Chen Zhihong)" target = "_blank">/a>
Summary:
This study is based on the CNAS-GL06: 2006 "Guidelines for the Evaluation of Uncertainty in Chemical Analysis", and analyzes and evaluates the uncertainty of the detection of ribavirin illegally added in veterinary drug powders by high performance liquid chromatography. The analysis results show that the peak area measurement of the instrument, the repeatability measurement of the sample and the preparation of the standard solution mother liquor are the main sources of uncertainty in the measurement of ribavirin in the veterinary drug Qingwen Baidu Powder, the uncertainty component introduced by the instrument peak area integral has the greatest influence on the total uncertainty. By selecting more precise instruments and standardizing operation, the uncertainty can be effectively reduced and the accuracy and reliability of the measurement results can be ensured. The paper provides a feasible analysis method for the measurement uncertainty assessment of ribavirin impurities in the production of Chinese veterinary powder, and is of great significance for reasonably characterizing the accuracy of the measurement results.
expand
keywords:
high performance liquid phase method veterinary drug powder ribavirin drug identification measurement uncertainty
Meeting time:
2011-11-11
meeting place:
Guangzhou
Organizer:
China Animal Husbandry and Veterinary Association of Central and South Six Provinces Association of Chinese and Western Veterinary Medicine
Last Update：2023-08-16 22:23:51
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Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
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Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
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Product Name: Guanidine Visit Supplier Webpage Request for quotationCAS: 113-00-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Aminomethanamidine Visit Supplier Webpage Request for quotation
CAS: 113-00-8
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Email: 3008007409@qq.com
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View History
Guanidinebase
ISOCYANATOTRIMETHYLSILANE
SODIUM MONOCHLORACETATE
ACETIC-13C2 ACID
PB-30239
1-Nitroso-2-phthol
E 101
FEMA 3233
CALFLO E
Norway saltpeter
ISOCYANATOTRIMETHYLSILANE
SODIUM MONOCHLORACETATE
ACETIC-13C2 ACID
PB-30239
1-Nitroso-2-phthol
E 101
FEMA 3233
CALFLO E
Norway saltpeter