Glycyl-L-glutamine
Glycyl-L-Glutamine
CAS: 13115-71-4
Molecular Formula: C7H13N3O4
Glycyl-L-glutamine - Names and Identifiers
| Name | Glycyl-L-Glutamine |
| Synonyms | Gly-Gln-OH Gly-L-Gln-OH glycylglutamine glycyl-L-glutamine Glycyl-L-Glutamine N2-Glycyl-L-glutamine L-GlutaMine, N2-glycyl- GlutaMine,N2-glycyl-, L- (8CI) (S)-5-AMino-2-(2-aMinoacetaMido)-5-oxopentanoic acid β-Endorphin (30-31) (bovine, camel, mouse, ovine)Gly-Gln |
| CAS | 13115-71-4 |
| EINECS | 700-144-0 |
| InChI | InChI=1/C7H13N3O4/c8-3-6(12)10-4(7(13)14)1-2-5(9)11/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14) |
Glycyl-L-glutamine - Physico-chemical Properties
| Molecular Formula | C7H13N3O4 |
| Molar Mass | 203.2 |
| Density | 1.359±0.06 g/cm3(Predicted) |
| Melting Point | 194°C |
| Boling Point | 643.1±55.0 °C(Predicted) |
| Specific Rotation(α) | -6.5 º (c=10, 2N HCl) |
| Flash Point | 342.7°C |
| Water Solubility | 154 g/L (20 ºC) |
| Solubility | Aqueous Acid (Slightly), Water (Slightly) |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | White to white-like powder |
| Color | White to Off-White |
| pKa | 3.11±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| Refractive Index | -7 ° (C=3, 1mol/L HC |
| MDL | MFCD00077124 |
| In vitro study | Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide. Glycyl-glutamine (Glycyl-L-glutamine) has an advantage over free glutamine(Gln) as growth factors for cell culture during both autoclaving and storage. |
| In vivo study | Glycyl-glutamine (Glycyl-L-glutamine) (0.3, 0.6, 1.0 and 10.0 nM) can dose-dependently inhibit beta-End-(1-31)-induced hypotension in pentobarbital-anesthetized rats. |
Glycyl-L-glutamine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | - |
| HS Code | 29241990 |
Glycyl-L-glutamine - Reference
| Reference Show more | 1. [IF=5.268] Bianjing Sun et al."Macroporous bacterial cellulose grafted by oligopeptides induces biomimetic mineralization via interfacial wettability."Colloid Surface B. 2019 Nov;183:110457 |
Glycyl-L-glutamine - Standard
Authoritative Data Verified Data
This product is glycyl-L-glutamine monohydrate. The content of C7H13N304 shall not be less than 99.0% calculated as anhydrous.
Last Update：2024-01-02 23:10:35
Glycyl-L-glutamine - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline or crystalline powder; Odorless.
- This product is soluble in water and insoluble in ethanol, acetone or ether.
specific rotation
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 40mg per lml, according to the law (General 0621), the specific rotation of a 1.2 ° to a 2.4 °.
Last Update：2022-01-01 11:34:24
Glycyl-L-glutamine - Differential diagnosis
Authoritative Data Verified Data
- take about 20mg of this product, add about 1 ml of water to dissolve, add 5 drops of ninhydrin test solution, heat, then show blue purple.
- take about 0.2g of this product, put it in a test tube, add 5ml of sodium hydroxide test solution, and slowly boil, that is, oxygen odor occurs, which can turn the moistened red litmus test paper blue.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
Last Update：2022-01-01 11:34:25
Glycyl-L-glutamine - Exam
Authoritative Data Verified Data
acidity
take this product L. 0g, add water 20ml dissolved, according to the law (General 0631),pH value should be 4.5-6.0.
transmittance of solution
take this product l. After being dissolved and diluted to 20ml with water, measure the transmittance at the wavelength of 430nm by UV-Vis spectrophotometry (General rule 0401), and the transmittance shall not be less than 98.0%.
clarity of the solution
take an appropriate amount of this product, add water to dissolve and dilute to make 0.lg of the solution, the solution should be clear, if it is turbid, compared with No. 1 turbidity standard solution (General 0902 first method), not more concentrated.
chloride
take 0.30g of this product and check it according to law (General rule 0801). Compared with the control solution made of 6.0ml of standard sodium chloride solution, it should not be more concentrated (0.02%).
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.02% of standard potassium sulfate solution, it should not be more concentrated ().
ammonium salt
take 0.10g of this product, vacuum distillation below 60°C, check according to law (General rule 0808), and compare with the control solution made of 0.10% of standard gasification ammonium solution, not deeper ().
determination of related substances by HPLC (General 0512)
- chromatographic conditions and system suitability test using amino bonded silica gel as filler; 0.05mol/L sodium dihydrogen phosphate solution (adjusted to pH 4.5 with phosphoric acid)-acetonitrile (35:65) mobile phase; The detection wavelength was 210mn. The theoretical plate number is not less than 2000 based on the glycyl-glutamine peak. Take 50mg of this product, put 50ml measuring flask half, add concentrated hydrogen peroxide solution 5ml, place for 30 minutes, dilute with mobile phase to scale, shake, as the system applicable solution, take 20u1 injection liquid chromatograph, record chromatogram. The resolution between glycyl-glutamine peak and adjacent impurity peak should meet the requirements.
- The determination method is to take an appropriate amount of this product, accurately weigh it, add the mobile phase to dissolve and dilute it to make it contain about l per lml. 0 mg solution, as the test solution; In addition, the appropriate amount of impurity I reference substance and impurity II reference substance, respectively, add the mobile phase to dissolve and dilute to make a solution containing about 0.5mg in each lml, as the reference solution; Respectively take the sample solution and the reference solution of 1ml, and put it in the same 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. Take the control solution 20u1 injection liquid chromatography, signal to noise ratio should be greater than 10. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, including impurity I and impurity II, the peak area shall be calculated according to the external standard method, and shall not exceed 0.5%; the Peak area of other single unknown impurities shall not be greater than 0.5 times (0.5%) of the peak area of glycyl-glutamine in the control solution; The peak area of other unknown impurities shall not be greater than the peak area of glycyl-glutamine in the control solution (1.0%). The peaks in the chromatogram of the test solution which were 0.05 times smaller than the peak area of glycyl-glutamine in the control solution were ignored.
other amino acids
take an appropriate amount of this product, add water to dissolve and dilute to prepare a solution of appropriate concentration, as a test solution; Take an appropriate amount of glycine, glutamine, glutamic acid and glycyl-glutamine, water is added to dissolve and dilute to make a solution of suitable concentration as a system-suitable solution. The separation and determination of glycine peak, glutamine peak, glutamic acid peak and glycyl-glutamine peak should meet the requirements by appropriate amino acid analyzer or high performance liquid chromatography. According to the external standard method to calculate the peak area, containing glycine not more than 1.0%, the total amount of glutamine and glutamic acid not more than 0.5%.
residual solvent
take this product 50mg, precision weighing, top empty bottle, precision add water lml to dissolve, sealed, as a test solution; Respectively, precision weighing ethanol, acetic acid, the appropriate amount of toluene was diluted with dimethyl sulfoxide to prepare the reference stock solution. The appropriate amount of each reference stock solution was accurately measured and diluted with water to prepare 25ug of ethanol per lml, A mixed solution of 250ug of ethyl acetate and 44.5ug of toluene was precisely weighed 1 ml, placed in a headspace bottle, sealed, and used as a reference solution. According to the test for determination of residual solvents (General rule 0861, second method), a capillary column with 5% phenyldimethicone (or similar polarity) as the stationary liquid; The initial temperature is 40°C, and the retention time is 6 minutes, the temperature was increased to 160°C at a rate of 10°C per minute for 3 minutes; The inlet temperature was 200°C; The detector temperature was 250°C; The equilibrium temperature of the headspace bottle was 80°C, the equilibration time was 40 minutes. The separation degree between the main peaks shall meet the requirements when the reference solution is injected in the headspace. The reference solution and the test solution were injected into the headspace, and the chromatogram was recorded. According to the external standard method, the residual amount of ethanol shall not exceed 0.05%, and the residual amount of ethyl acetate and toluene shall comply with the regulations.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the moisture content should be 7.0% ~ 9.0%.
ignition residue
take this product, check according to law (General 0841), residue shall not exceed 0.1%.
Iron Salt
take l.Og of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
Heavy metals
take 2.0g of this product, inspection according to law (General rule 0821 third law), containing heavy metals shall not exceed 5 parts per million.
arsenic salt
take 2.0g of this product, add 23ml to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take this product, check according to law (General rule 1143), each lg glycyl glutamine containing endotoxin amount should be less than 6EU. (For injection)
Last Update：2022-01-01 11:34:26
Glycyl-L-glutamine - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add anhydrous formic acid 2ml, glacial acetic acid 40ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 20.32mg of C7H13N3O4.
Last Update：2022-01-01 11:34:27
Glycyl-L-glutamine - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 11:34:27
Glycyl-L-glutamine - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:34:27
Glycyl-L-glutamine - Reference Information
| LogP | -6.25--5.12 at 25℃ and pH1-13 |
| surface tension | 71.9mN/m at 1g/L and 20 ℃ |
| preparation | using glycine and L-glutamine as the main raw materials, glycine is protected by phthalic anhydride first, the obtained intermediate product and thionyl chloride generate acyl chloride, then amidation with L-glutamine, and finally deprotection with hydrazine hydrate in methanol to obtain the product, and the crude product can reach the pharmaceutical level after one-time refining. |
| Use | Glycyl-L-glutamine is used as a thermostable substitute for glutamine in mammalian cell culture medium. As an amino acid nutritional drug, it can be used to improve the cellular immune function of patients. Effectively reduce the risk of infection in critically ill patients, especially for the treatment and recovery of critically ill patients such as severe infections and malignant tumors. APIs can be used as drugs alone, can also be compounded with other amino acids, and can also develop health products. |
| biological activity | Glycyl-glutamine (Glycyl-L-glutamine), an enzyme cleavage product of β-endorhin, is an endogenous antagonist of β-endorphin (1-31). Glycyl-glutamine (Glycyl-L-glutamine) is an active neuropeptide that is more stable than glutamine (Gln). |
Last Update：2024-04-09 20:13:35
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View History
Glycyl-L-glutamine
甲酸铯水合物
聚乙二醇6000
2172563-27-6
132839-58-8
2250198-69-5
Ethyl ester of hexanoic acid
56180-94-0
L-9-ANTHRYLALANINE
酸性镀铜光亮剂
甲酸铯水合物
聚乙二醇6000
2172563-27-6
132839-58-8
2250198-69-5
Ethyl ester of hexanoic acid
56180-94-0
L-9-ANTHRYLALANINE
酸性镀铜光亮剂