GYPENOSIDE-XVII
GypenosideXVII
CAS: 80321-69-3
Molecular Formula: C48H82O18
GYPENOSIDE-XVII - Names and Identifiers
GYPENOSIDE-XVII - Physico-chemical Properties
| Molecular Formula | C48H82O18 |
| Molar Mass | 947.15 |
| Density | 1.38 |
| Melting Point | >183°C (dec.) |
| Boling Point | 1013.5±65.0 °C(Predicted) |
| Specific Rotation(α) | +18.3°（c=0.30,MeOH） |
| Solubility | Soluble in water, methanol, ethanol, soluble in hot water, insoluble in ethyl/ether, chloroform and benzene. |
| Appearance | White powder |
| Color | White to Off-White |
| pKa | 12.90±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD10566703 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from gynostemma pentaphyllum (seven leaf bile) Fiveleaf Gynostemma Herb. |
| In vitro study | The ability of Gypenoside XVII (GP-17) to prevent Ox-LDL-induced cytotoxicity is detected by cell viability assays. Gypenoside XVII does not demonstrate any cytotoxicity in HUVECs. Gypenoside XVII can protect HUVECs against Ox-LDL-induced apoptosis. Gypenoside XVII dose-dependently mitigates the toxic effect of Ox-LDL on HUVEC viability. The viability of HUVECs is significantly higher than that of other groups at 50 μg/mL Gypenoside XVII . |
| In vivo study | Body weights are measured as physical measures of hormone bioactivity. Mean body weights are significantly higher in every group compared to that of the control, but there is no significant difference in body weight between the different treatments during the 10-week feeding. The mouse plasma lipid levels are also measured at the end of 10 weeks of a high-fat diet. Circulating levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are significantly increased in the treated groups of ApoE -/- mice compared with those of the C57BL/6J control group; Gypenoside XVII (GP-17) and Probucol treatment substantially decreases both of these parameters relative to those of the ApoE -/- model group. |
GYPENOSIDE-XVII - Reference
| Reference Show more | 1. Yang Meichao, Wu, Jingdong. Effects of Escin XVII on UV-induced endoplasmic reticulum stress-related molecules in mice [J]. Journal of Chengdu University of Traditional Chinese Medicine 2019(2). 2. Wang tingou, Wu Jingdong. Effects of gypenosides aescinoside XVII on the levels of prostaglandin 2 and cyclooxygenase 2 in serum and the expression of MMP-1 in skin tissue of photoaging mice [J]. Chinese medical journal, 2019,34(05):1012-1015. 3. Li Xueqing, Li Li, Liu Xuefeng, etc. Study on the metabolism of Panax notoginseng saponins in human intestinal flora [J]. Pharmaceutical Biology technology, 2017(03):34-39. 4. [IF = 3.935] Hong Zhang et al."A multi-dimensional analytical approach based on time-decoupled online comprehensive two-dimensional chromatography coupled with mobility quadpole time-of-flight mass spectrum for the analysis of anesthesia from a white . [IF = 3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 6. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 7. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 |
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