| Molecular Formula | C22H27N5O3 |
| Molar Mass | 409.48 |
| Density | 1.247±0.06 g/cm3(Predicted) |
| Boling Point | 545.9±50.0 °C(Predicted) |
| Solubility | DMSO: ≥ 29 mg/mL |
| Appearance | solid |
| Color | White |
| pKa | 13.03±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vivo study | The ip route of administration would be suitable for dosing GSK6853 in potential PK/PD models. |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.442 ml | 12.211 ml | 24.421 ml |
| 5 mM | 0.488 ml | 2.442 ml | 4.884 ml |
| 10 mM | 0.244 ml | 1.221 ml | 2.442 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.488 ml |
| Use | GSK6853 can be used in biological studies for preparing bromodomain and PHD finger-containing protein inhibitors. |
| biological activity | GSK6853 is a strong and selective inhibitor of RPF1 acetyllysine (pKd = 9.5), its selectivity is 1600 times that of other acetyl lysine. |
| in vivo study | The ip route of administration would be recommended for dozing GSK6853 in potential PK/PD models. |