GSK1265744
Cabotegravir
CAS: 1051375-10-0
Molecular Formula: C19H17F2N3O5
GSK1265744 - Names and Identifiers
GSK1265744 - Physico-chemical Properties
| Molecular Formula | C19H17F2N3O5 |
| Molar Mass | 405.35 |
| Density | 1.57±0.1 g/cm3(Predicted) |
| Boling Point | 664.0±55.0 °C(Predicted) |
| Solubility | DMSO: 12.67 mg/mL |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | GSK1265744 inhibitors HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM against St HIV-1 Ba-L and NL432, review. GSK1265744 produce cytotoxicity with CC50 of 6.4, 5.0, 9.2, and 13 μm in proliferating IM-9, U-937, MT-4, and Molt-4 cell lines, review. GSK1265744 inhibits HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM for HIV-1 and NL432, respectively. GSK1265744 produced cytotoxicity in the proliferating IM-9,U-937,MT-4, and Molt-4 cell lines with CC50 of 6.4,5.0,9.2, and 13 μm, respectively. |
| In vivo study | GSK1265744 (50 mg/kg) treatment of proteins rhesus macahydrate against three high-dose SHIV challenges. GSK1265744 (50 mg/kg) prevented infection of rhesus monkeys with three high doses. |
GSK1265744 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.467 ml | 12.335 ml | 24.67 ml |
| 5 mM | 0.493 ml | 2.467 ml | 4.934 ml |
| 10 mM | 0.247 ml | 1.233 ml | 2.467 ml |
| 5 mM | 0.049 ml | 0.247 ml | 0.493 ml |
Last Update：2024-01-02 23:10:35
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