GLPG0634
GLPG0634
CAS: 1206161-97-8
Molecular Formula: C21H23N5O3S
GLPG0634 - Names and Identifiers
GLPG0634 - Physico-chemical Properties
| Molecular Formula | C21H23N5O3S |
| Molar Mass | 425.5 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Melting Point | 229 - 231°C |
| Solubility | DMSO: 6.8 mg/mL |
| Appearance | solid |
| Color | Off-white |
| pKa | 8.04±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| In vitro study | In cell lines, GLPG0634 inhibited IL-2-and IL-4-induced JAK1/JAK3/γc signaling and IFN-αB2-induced JAK1/TYK2 type II receptor signaling with IC50 values ranging from 150 to 760 nM. GLPG0634 shows higher selectivity for JAK1 kinase than JAK2 kinase in the JAK/STAT signal at the cellular level. In addition, GLPG0634 also inhibits the differentiation of Th1,Th2, and Th17 cells. |
| In vivo study | After oral administration, absolute bioavailability was moderate in rats (45%) and high in mice (∼ 100). In rat and mouse CIA models, Filgotinib (30 mg/kg daily (RAT);50 mg/kg twice daily (mouse)) dose-dependently reduced inflammation, cartilage, and bone degeneration. In vivo studies with Filgotinib (GLPG0634) in DSS-treated mice showed that inhibition of JAK1 was sufficient to achieve strong efficacy in a preclinical mouse model, correlating with inhibition of STAT3 phosphorylation in inflamed colon. |
GLPG0634 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.35 ml | 11.751 ml | 23.502 ml |
| 5 mM | 0.47 ml | 2.35 ml | 4.7 ml |
| 10 mM | 0.235 ml | 1.175 ml | 2.35 ml |
| 5 mM | 0.047 ml | 0.235 ml | 0.47 ml |
Last Update：2024-01-02 23:10:35
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Product Name: N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide Request for quotationCAS: 1206161-97-8
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Featured ProductsSpot supply
Product Name: Filgotinib (GLPG0634) Visit Supplier Webpage Request for quotationCAS: 1206161-97-8
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Product Name: GLPG0634 Request for quotation
CAS: 1206161-97-8
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 1206161-97-8
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
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Product Name: GLPG0634 Request for quotationCAS: 1206161-97-8
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Spot supply
Product Name: N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide Request for quotationCAS: 1206161-97-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Filgotinib Visit Supplier Webpage Request for quotationCAS: 1206161-97-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: GLPG0634 Visit Supplier Webpage Request for quotationCAS: 1206161-97-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: GLPG0634 Visit Supplier Webpage Request for quotationCAS: 1206161-97-8
Tel: 18301782025
Email: 3008007409@qq.com
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View History
GLPG0634
Trna Type Xxi
Diethylenimide oxide
Insulin injection
Refrigerant R 123
7664-41-7
Solkane 123
azanium
Trna Type Xxi
Diethylenimide oxide
Insulin injection
Refrigerant R 123
7664-41-7
Solkane 123
azanium