Furaxon
Furazolidone
CAS: 67-45-8
Molecular Formula: C8H7N3O5
Furaxon - Names and Identifiers
Furaxon - Physico-chemical Properties
| Molecular Formula | C8H7N3O5 |
| Molar Mass | 225.16 |
| Density | 1.5406 (rough estimate) |
| Melting Point | 254-256°C (dec.) |
| Boling Point | 366.66°C (rough estimate) |
| Flash Point | 2 °C |
| Water Solubility | 极微溶于氯仿、水、乙醇和四氯化碳，1L水中溶40mg该品。稍溶于二甲基甲酰胺。 |
| Solubility | Soluble in chloroform, water, ethanol and carbon tetrachloride, 11g of water soluble 40mg of the product. Slightly soluble in dimethylformamide. |
| Vapor Presure | 3.59E-05mmHg at 25°C |
| Appearance | Pale yellow crystalline powder |
| Color | yellow |
| Maximum wavelength(λmax) | ['365nm(DMSO)(lit.)'] |
| Merck | 14,4300 |
| BRN | 8317414 |
| pKa | -1.98±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Sensitive | Light Sensitive |
| Refractive Index | 1.7180 (estimate) |
| MDL | MFCD00010550 |
| Physical and Chemical Properties | Light yellow crystalline powder, odorless, bitter. Melting point 275 °c (decomposition). Insoluble in water, ethanol, slightly soluble in chloroform, slightly soluble in dimethylformamide. Mouse oral LD501.5-4.54g/kg. |
| Use | The product is a broad antibacterial spectrum of fungicides. As an anti-infective drug, it is effective against a variety of gram-positive and negative Escherichia coli, Bacillus anthracis, paratyphoid Bacillus, etc., for the treatment of bacillary dysentery, enteritis, also for vaginal infection, in recent years for the treatment of typhoid fever, the curative effect is good. As an additive for animal drugs and beverages, it has a special effect on salmonella, such as chicken White dysentery and Escherichia coli |
Furaxon - Risk and Safety
| Risk Codes | R62 - Possible risk of impaired fertility R40 - Limited evidence of a carcinogenic effect R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R68 - Possible risk of irreversible effects |
| Safety Description | S36 - Wear suitable protective clothing. S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| WGK Germany | 3 |
| RTECS | RQ3675000 |
| TSCA | Yes |
| HS Code | 29349990 |
Furaxon - Upstream Downstream Industry
| Raw Materials | Acetic anhydride 2-Furaldehyde Urea Ethanolamine |
Furaxon - Reference
| Reference Show more | 1. Yu Hao, Wang Tingting, hechunxiang, etc. Electrocatalytic reduction of furazolidone by Poly (O-aminophenol) functional membrane [J]. Journal of Science of Normal University, 2017(1). 2. Liang Jinling, Tang Ke, Huang Yuxia et al. Molecular Simulation and verification of furacilin Molecularly Imprinted Polymer [J]. Computer and applied chemistry 2018(5). |
Furaxon - Introduction
Open Data Unverified Data
Furazolidone (Furazolidone, once named Furazolidone) is a nitrofuran antibiotics, can be used to treat bacteria and protozoa caused by dysentery, enteritis, gastric ulcer and other gastrointestinal diseases. Furazolidone is a broad-spectrum antibacterial drug, which has inhibitory effect on common gram-negative and positive bacteria. The People's Republic of China, the Ministry of Agriculture listed furazolidone as a prohibited drug, not detected in animal foods. The FDA also banned the use of nitrofurans, including furazolidone, in animal-based foods in 2002. Generally should not be used for patients with ulcer disease or bronchial asthma. Alcohol consumption during oral administration of this product can cause disulfiram-like reactions, manifested as skin flushing, itching, Fever, Head Pain, Nausea, Abdominal Pain, tachycardia, elevated blood pressure, chest tightness, irritability, etc, therefore, alcohol use was prohibited during the treatment and within 5 days after drug withdrawal.
Last Update：2022-01-01 08:49:20
Furaxon - Nature
Open Data Verified Data
light yellow crystalline powder, odorless, bitter. Insoluble in water and ethanol, slightly soluble in chloroform, slightly soluble in dimethylamide.
Last Update：2024-01-02 23:10:35
Furaxon - Preparation Method
Open Data Verified Data
The furazolidone was obtained by condensation of ethanolamine with urea, nitrosation with sodium nitrite, cyclization, and finally reduction with iron powder and condensation with 5-nitro-2-furfuryl glycol diacetate and formaldehyde.
Last Update：2025-06-10 22:55:16
Furaxon - Standard
Authoritative Data Verified Data
This product is 3-[[(5-nitro-2-furyl) methylene] amino]-2-oxazolidinone. The content of C8H7N305 shall be between 97.0% and 103.0% based on the dry product.
Last Update：2024-01-02 23:10:35
Furaxon - Trait
Authoritative Data Verified Data
- This product is yellow powder or crystalline powder; Odorless.
- This product is slightly soluble in N ,N-dimethylformamide, slightly soluble in chloroform, and almost insoluble in water, ethanol or ether.
Last Update：2022-01-01 11:56:40
Furaxon - Introduction
Soluble in chloroform, water, ethanol and carbon tetrachloride, 11g of water soluble 40mg of the product. Slightly soluble in dimethylformamide. No smell, bitter taste.
Last Update：2022-10-16 17:27:50
Furaxon - Nature
Open Data Unverified Data
melting point 254-256°C (dec.)
Storage Conditions 0-6°C
Merck 13,4321
Stable. Combustion. Compatible with strong oxidizing agents.
NIST chemical substance information Furazolidone(67-45-8)
EPA chemical substance information 2-Oxazolidinone, 3-[[(5-nitro-2-furanyl)methylene] amino]-(67-45-8)
Last Update：2022-01-01 08:49:21
Furaxon - Application
Open Data Verified Data
nitrofuran antibacterial drugs. The antibacterial spectrum was similar to that of furanoidine. Its mechanism of action is to interfere with bacterial oxidoreductase, thereby blocking the normal metabolism of bacteria. It has antibacterial effect on Salmonella, Shigella, Escherichia coli, Proteus, streptococcus and Staphylococcus. Bacteria resistant to the product is not easy to produce resistance, and there is no cross resistance to sulfonamides and antibiotics. Mainly used for bacillary dysentery, enteritis, typhoid, paratyphoid and external treatment of vaginal trichomoniasis.
Last Update：2025-08-19 16:24:40
Furaxon - Differential diagnosis
Authoritative Data Verified Data
- take about 20mg of this product, add 5ml of ethanol and 3ml of sodium hydroxide solution (l-10), which shows red color.
- take about 1 mg of this product, add N ,N-dimethylformamide 0.1ml to dissolve, add 5ml of water, 1ml of sodium nitroprusside test solution and 1ml of sodium hydroxide test solution, shake well, and place for 2 minutes. The solution is initially olive green, gradually dark green (different from nitrofurazone and nitrofurantoin).
- take the test solution under the content determination item and measure it by ultraviolet-visible spectrophotometry (General rule 0401), which has the maximum absorption at the wavelength of Nm, there is minimal absorption at a wavelength of 302nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 182).
Last Update：2022-01-01 11:56:40
Furaxon - Antibacterials
Open Data Unverified Data
furazolidone is what we usually call furazolidone, is a nitrofuran antibacterial drugs, gram-positive and negative bacteria have a certain antibacterial effect, including Salmonella, Shigella, escherichia coli, Pneumonia Klebsiella, Enterobacter, Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Vibrio cholerae, Campylobacter, Bacteroides, etc, giardia is also active. Its mechanism of action is to interfere with bacterial oxidoreductases and thereby block the normal metabolism of the bacteria. Mainly used for the treatment of various intestinal infections, bacillary dysentery, Diarrhea, enteritis, colibacillosis septicemia, typhoid, cholera, Transmissibility rhinitis, blackhead disease, trichomoniasis, it can also be used in combination with drugs such as antacids to treat antral gastritis caused by Helicobacter pylori.
Furazolidone on infants and young children do have side effects, such as liver and kidney damage, allergic reactions, etc., so it is generally recommended to use as little as possible or not.
Last Update：2022-01-01 08:49:22
Furaxon - Exam
Authoritative Data Verified Data
acidity
Take lg of this product, add 100ml of water, shake for 15 minutes, filter, take the filtrate to determine according to law (General rule 0631),pH value should be 5-5~7.0.
dissolved in ethanol
take 5g of this product, put it in a 250ml Erlenmeyer flask, add 100ml of ethanol, heat and reflux for 5 minutes, let it cool to 25°C and 2°C, then filter it with a 5# vertical melting funnel, the residue was washed with 50ml of ethanol, the washing liquid was combined with the filtrate, and the residue was placed in a weighed evaporation dish. The ethanol was distilled off, and the residue was dried at 80 ° C. For 1 hour, and the remaining residue should not exceed 0.5%.
S-Nitro Bran-diacetate
operation in the dark. Take about 50mg of this product, precision weighing, 10ml measuring flask, add N, N-dimethylformamide 5ml, put the water bath to dissolve, cool, dilute with acetone to the scale, shake well, as a test solution; Another 5-nitrofurfural diacetate standard amount, plus N, N-dimethylformamide-acetone (1:1) the solution was dissolved and quantitatively diluted to prepare a solution containing 50ug per 1 ml as a control solution. According to the thin layer chromatography (General 0502) test, absorb 20 u1 of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with toluene-dioxane (95:5) as the developing solvent, expand, take out, dry, dry at 105°C for 5 minutes, spray with phenylhydrazine hydrochloride solution (take phenylhydrazine hydrochloride 0.75g, add ethanol 10ml to dissolve, dilute with water to 50ml, decolorize with activated carbon, filter, take the whole filtrate, add hydrochloric acid 25ml, add water to 105 ml), and heat at °C for 5 minutes. For the test solution, if the impurity spot corresponding to the main spot of the reference solution, its color should not be deeper (1.0%) compared with the main spot of the reference solution.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.2%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 11:56:41
Furaxon - Fungicides for aquaculture
Open Data Unverified Data
- furazolidone has little toxicity to fish, turtle and the like, and can be used as both prevention and treatment of early diseases in freshwater fisheries. When the water temperature is below 20 ° C, 20~30 minutes of immersion; Water temperature above 20 ° C, 10~15 minutes of immersion. When the water temperature is about 20 ℃, furazolidone concentration of 0.025ppm can inhibit a variety of pathogenic bacteria, in the pool, water tank raised goldfish, tropical fish to withstand the concentration of 1.5ppm, will not die. Therefore, in case of serious illness, you can use the concentration of 0.4 ~ 1.0ppm, the whole pool after spraying the drug, the fish should be fed with high quality commodity feed, ornamental fish must be fed live water fleas, Cyclops, chironomid larvae, water earthworms and other animal food, strengthen the nutrition of diseased fish, enhance the disease resistance of diseased fish. Prevention of white head and mouth disease of domestic fish, gill disease, printing disease, vertical scale disease, red skin disease, etc., 1 time before stocking. Prevention of ornamental fish white head and mouth disease, gill disease, vertical scale disease, fin and tail decay disease, in small water, 1 times a day, at intervals of 1 day, the patient was washed again. Treatment of ornamental fish white head and mouth disease, gill rot disease, vertical scale disease, fin and tail decay disease, etc., 1 times a day, every 1 day, can be continuous immersion 3~5 times, until the disease disappeared, the fish body to restore health.
- furazolidone residues can cause potential harm to humans, can cause hemolytic anemia, polyneuritis, eye damage and acute liver necrosis and other disabilities, has been banned by China, the European Union and other countries.
Last Update：2022-01-01 08:49:23
Furaxon - Content determination
Authoritative Data Verified Data
operation in the dark. Take about 20mg of this product, precision weighing, 250ml measuring flask, add N,N-dimethylformamide 40ml, shake to dissolve, dilute with water to the scale, shake, precision take 10ml, set it in a 100ml measuring flask, dilute it to the scale with water, shake it well, use it as a test solution, and measure the absorbance at the wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (general rule); another furazolidone reference substance was determined by the same method and calculated.
Last Update：2022-01-01 11:56:42
Furaxon - Chemical properties
Open Data Unverified Data
light yellow crystalline powder, odorless, bitter. Melting point 275 °c (decomposition). Insoluble in water, ethanol, slightly soluble in chloroform, slightly soluble in dimethylformamide. Mouse oral LD501.5-4.54g/kg.
Last Update：2022-01-01 08:49:23
Furaxon - Category
Authoritative Data Verified Data
antibacterial drugs.
Last Update：2022-01-01 11:56:42
Furaxon - Production method
Open Data Unverified Data
- β-Hydroxyethyl urea was obtained by condensation with urea using ethanolamine as a raw material, and cyclized by nitrosation to obtain 3-nitroso-2-oxazolidinone. Further reduction with iron powder, then condensation with 5-nitro-2-furfuryl glycol diacetate and formaldehyde to obtain furazolidone.
- β-Hydroxyethyl urea is produced by the condensation of ethanolamine and urea, and 3-nitroso-2-oxazolone is further obtained by nitrosation with sodium nitrite. After reduction with iron powder, it was condensed with 5-nitro-2-furfuryl glycol diacetate and formaldehyde to obtain furazolidone.
Last Update：2022-01-01 08:49:24
Furaxon - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:56:42
Furaxon - Safety Information
Open Data Unverified Data
marking of dangerous goods Xn
Hazard code 62-40
Safety instructions 36-22
WGK Germany 3
RTECS#: RQ3675000
Customs Code 29349990
Toxic Substance Data 67-45-8(Hazardous Substances Data)
Last Update：2022-01-01 08:49:24
Furaxon - Furazolidona Tablets
Authoritative Data Verified Data
This product contains furazolidone (C8H7N305) should be the label amount of 90.0% ~ 110.0%.
trait
This product is yellow tablet or sugar-coated tablet, yellow after removing the coating.
identification
- take an appropriate amount of fine powder of this product (equivalent to 30mg of furazolidone), add 10ml of ethanol, heat it in a water bath for 5 minutes, let it cool, filter, take 5ml of filtrate, add sodium hydroxide solution (l-10)3ml, that is, red.
- 1ml of the above-mentioned remaining filtrate was taken, ethanol was distilled off on a water bath, and the residue showed the same reaction according to the Identification Test (2) under the item of furazolidone.
- take the test solution under the content determination item and measure it by ultraviolet-visible spectrophotometry (General rule 0401), which has the maximum absorption at the wavelength of Nm, there is minimal absorption at a wavelength of 302nm.
examination
- Content uniformity protected from light. Take 1 tablet of this product (lOmg specification), put it in mortar, grind it fine, add 40ml of N,N-dimethylformamide to 250ml measuring flask, shake to dissolve furazolidone, dilute it with water to the scale, shake well, filter, take 10ml of continuous filtrate with precision, put it in 50ml measuring flask, dilute it with water to scale, shake well, and use it as test solution. Determination of content according to the content determination method, should comply with the provisions (General 0941).
- dissolution rate protected from light. Take this product, according to the dissolution and release determination method (General 0931 second method), to 1. 3% sodium dodecyl sulfate solution 1000ml as dissolution medium, rotating speed of 120 rpm, operated according to law, after 60 minutes, take the solution filtration, take filtrate (lOmg specifications) or take an appropriate amount of continued filtrate accurately and dilute with water to prepare a solution containing about 10ug furazolidone per 1 ml (30mg specification and lOOmg specification) as a test solution, measure absorbance at the wavelength of 367nm according to UV-visible spectrophotometry (General rule 0401); Take another 20mg of furazolidone reference substance, weigh it accurately, put it in a 200ml measuring flask, add N ,N-dimethylformamide (20ml) was dissolved, diluted with water to scale, shaken, and then 5ml was accurately measured. The solution was placed in a 50ml measuring flask, diluted with water to scale, and shaken well, the dissolution amount of each tablet was calculated. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
operation in the dark. Take 10 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to 20mg of furazolidone), put it in a 250ml measuring flask, add 40ml of dimethylformamide, shake to dissolve furazolidone, dilute to the scale with water, shake, filter, take 10ml of filtrate accurately, put it in a 100ml measuring flask, dilute to the scale with water, shake well, as a test solution, measure absorbance at the wavelength of 367nm according to UV-visible spectrophotometry (General rule 0401); Take another 20mg of furazolidone reference substance, weigh it accurately, put it in a 250ml measuring flask, add N,N-dimethylformamide 40ml, shake to dissolve, dilute to scale with water, shake well, take 10ml accurately, put it in a 100ml measuring flask, dilute to scale with water, shake well, as a reference solution, the same method of determination, calculation, that is.
category
Same as furazolidone.
specification
(l)10mg (2)30mg (3)100mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:56:43
Furaxon - Dosage and usage
Open Data Unverified Data
oral, adult 0.1g/time, 3~4 times/day; Children daily 5mg ~ 10mg/kg, divided into 4 times.
- Nausea, Vomit and other common gastrointestinal reactions, sometimes allergic reactions such as urticaria, drug fever and asthma.
- This product can also cause multiple neuritis.
Last Update：2022-01-01 08:49:25
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View History
Furaxon
Betamethasone
2-Adamantanone
TRIS(2-FURYL)PHOSPHINE
Chemaid
66532-85-2
PENTANOIC ANHYDRIDE
1002-36-4
硼酸钠
Ruthenium (Ⅲ) chloride
Betamethasone
2-Adamantanone
TRIS(2-FURYL)PHOSPHINE
Chemaid
66532-85-2
PENTANOIC ANHYDRIDE
1002-36-4
硼酸钠
Ruthenium (Ⅲ) chloride
Raw Materials for Furaxon