Formylmelphalan
Phosphorous oxybromide
CAS: 7789-59-5
Molecular Formula: Br3OP
Formylmelphalan - Names and Identifiers
Formylmelphalan - Physico-chemical Properties
| Molecular Formula | Br3OP |
| Molar Mass | 286.69 |
| Density | 2.82g/mLat 25°C(lit.) |
| Melting Point | 56°C(lit.) |
| Boling Point | 192°C(lit.) |
| Flash Point | 189°C |
| Water Solubility | decomposes |
| Vapor Presure | 0.786mmHg at 25°C |
| Appearance | Lump |
| Specific Gravity | 2.822 |
| Color | White to yellow |
| Merck | 14,7348 |
| Storage Condition | Store below +30°C. |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.613 |
| Physical and Chemical Properties | Appearance of colorless or light orange crystals, with irritating odor |
| Use | It is used as an intermediate in chemical processing and as a raw material for the manufacture of brominated flame retardants. |
Formylmelphalan - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R14 - Reacts violently with water R34 - Causes burns R37 - Irritating to the respiratory system |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.) S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S7/8 - SNeverusewater. - |
| UN IDs | UN 1939 8/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | Yes |
| HS Code | 28129090 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
Formylmelphalan - Nature
Open Data Verified Data
colorless or light orange crystals with irritating odor. The relative density was 2. 822. Melting point 56 °c. Boiling point 191.7 °c. The heat of vaporization was 38kJ/mol. Soluble in ether, benzene, chloroform, carbon disulfide, concentrated sulfuric acid. Slow hydrolysis in water to phosphoric acid and HBr.
Last Update：2025-06-10 22:55:16
Formylmelphalan - Preparation Method
Open Data Verified Data
- phosphorus oxychloride method: phosphorus oxychloride is used as raw material, aluminum trichloride is used as catalyst, heating, and hydrogen bromide gas is introduced to react at a temperature of about 80 ° C. To obtain phosphorus oxybromide. The hydrogen chloride gas generated by the reaction is absorbed by water to generate dilute hydrochloric acid.
- phosphorus tribromide process: in a round-bottom flask equipped with a mill-orifice reflux condenser, add a mixture of phosphorus pentaboride and phosphorus pentoxide (250g PBrs/approximately 30g P2 05), it was slowly heated to 150 ℃, and phosphorus pentoxide was slightly more than phosphorus pentabromide according to stoichiometry. At this time, the reaction was terminated within 5h while removing bromine. Next, lOg of bromine and an equivalent amount of phosphorus pentoxide were added to the melt and refluxed at 150 °c for several hours. This is due to the time required for the oxidation of the intermediate phosphorus tribromide to phosphorus pentabromide and for the conversion to phosphorus tribromide. The resultant was subjected to vacuum distillation under reduced pressure. After the bromine of the initial fraction and the phosphorus tribromide contained therein are removed, trapping is performed. The receiver was cooled with ice-saline. Phosphorus tribromo was prepared.
Last Update：2022-01-01 11:02:43
Formylmelphalan - Application
Open Data Verified Data
It is used as an intermediate in a chemical process and as a raw material for producing a bromine-based flame retardant.
Last Update：2025-08-19 16:24:40
Formylmelphalan - Safety
Open Data Verified Data
risk code: acid corrosion product, GB8, Class 1 81055. UN No. 2576 (molten);IMDG CODE P. 8206, 8, category 1. Glass bottles or polyethylene plastic bottles, each bottle of net weight 500g, and then concentrated in the wood box liner, or metal barrel lined with plastic bags, net weight 25kg per barrel. The package should be marked with "drug" and "corrosive substances. Store in a cool, dry, well-ventilated warehouse. Isolation storage and transportation of combustible materials, especially fibrous organic matter. Keep away from electrical equipment to avoid corrosion. Take precautions against damp. Light load and light discharge during handling to prevent damage to the container. Fire, dry sand, dry powder can be used to extinguishing. Fire of nearby combustibles can be put out with water, but the direct flow of water to the phosphorus tribromo must be prevented. It has similar toxicity to phosphorus oxychloride. It reacts with water and emits white, smoky, irritating and corrosive hydrogen bromide gas, which is strongly irritating to the eyes, mucous membranes and skin. Patients who inhale vapor or smoke should be removed from the contaminated area, placed to rest and kept warm. The patient has eye irritation and is flushed with water. Skin contact first rinse with water, then wash thoroughly with soap. If there is a burn, see a doctor for diagnosis and treatment. The patient was immediately sent to the hospital for treatment.
Last Update：2025-06-10 22:55:16
Formylmelphalan - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | phosphorus oxybromide is a colorless or light orange crystal with pungent odor, soluble in ether, benzene, chloroform, carbon disulfide, concentrated sulfuric acid. Slow hydrolysis in water to phosphoric acid and HBr. Phosphorus oxybromide is used as an intermediate in chemical processing and as a raw material for the manufacture of brominated flame retardants. |
| toxicity | has toxicity similar to that of phosphorus oxychloride. It reacts with water and emits white, smoky, irritating and corrosive hydrogen bromide gas, which is strongly irritating to the eyes, mucous membranes and skin. Patients who inhale vapor or smoke should be removed from the contaminated area, placed to rest and kept warm. The patient has eye irritation and is flushed with water. Skin contact first rinse with water, then wash thoroughly with soap, if there is a burn treatment. The patient was immediately sent to the hospital for treatment. |
| Use | is used as an intermediate in chemical processing and as a raw material for the manufacture of brominated flame retardants. |
| production method | phosphorus oxychloride method with phosphorus oxychloride as raw material, aluminum chloride as catalyst, heated at about 80 ℃, hydrogen bromide gas was introduced into the reaction to obtain tribromophosphorus. The hydrogen chloride gas generated by the reaction of POC13 3HBr → POBr3 3HCl is absorbed by water to generate dilute hydrochloric acid. Phosphorus tribromide method a mixture of phosphorus pentabromide and phosphorus pentoxide (250 gPBr5/about 30 gP2O5) was added to a round-bottom flask equipped with a mill-orifice reflux condenser and slowly heated to 150 °c, the amount of phosphorus pentoxide was slightly higher than that of phosphorus pentabromide according to stoichiometry. At this time, the reaction was terminated within 5h while removing the bromine. Next, 10g of bromine and an equivalent amount of phosphorus pentoxide were added to the melt and refluxed at 150 ° C. For several hours. This is due to the time required for the oxidation of the intermediate phosphorus tribromide to phosphorus pentabromide and for the conversion to phosphorus tribromide. The resultant was subjected to vacuum distillation under reduced pressure. After the bromine of the initial fraction and the phosphorus tribromide contained therein are removed, trapping is performed. The receiver was cooled with ice-saline. Phosphorus tribromo was prepared. 3PBr5 P2O5 → 5POBr3 |
| category | corrosive article |
| flammability hazard characteristics | toxic hydrogen bromide gas generated by water decomposition |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from combustible materials |
| extinguishing agent | dry powder |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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