Fmoc-N-Me-Nle-Oh
Fmoc-N-Methyl-L-Norleucine
CAS: 112883-42-8
Molecular Formula: C22H25NO4
Fmoc-N-Me-Nle-Oh - Names and Identifiers
Fmoc-N-Me-Nle-Oh - Physico-chemical Properties
| Molecular Formula | C22H25NO4 |
| Molar Mass | 367.44 |
| Density | 1.196±0.06 g/cm3(Predicted) |
| Boling Point | 542.6±29.0 °C(Predicted) |
| Appearance | Solid |
| pKa | 3.92±0.21(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ WGK Germany:3 |
Fmoc-N-Me-Nle-Oh - Risk and Safety
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
Fmoc-N-Me-Nle-Oh - Introduction
Fmoc-N-methyl-L-norleucine (Fmoc-N-Me-L-leucine) is an organic compound with some unique properties and uses. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: A white solid
-Molecular formula: C21H25NO4
-Molecular weight: 355.43g/mol
-Melting point: 108-112°C
-Storage conditions: Store in a low temperature, dry and ventilated place
Use:
Fmoc-N-methyl-L-norleucine is an important organic synthesis intermediate, which is widely used in the field of peptide synthesis. Its main uses include:
-Peptide synthesis: As a building block of amino acid fragments, it is used for the synthesis of polypeptide chains and research in the field of protein engineering.
-Drug development: research and development for the synthesis of peptide-related drugs and other biologically active molecules.
-Chemical biology: used to synthesize peptide probes and labels, used to study biological processes and the mechanism of cell signaling.
Preparation Method:
The preparation method of Fmoc-N-methyl-L-norleucine is mainly obtained by organic synthesis reaction, the specific steps include:
1. First, L-norleucine is reacted with a methylating agent to replace the hydrogen atom on the amino group with a methyl group.
2. Next, the obtained product is reacted with an Fmoc group compound to introduce an amino protecting group.
3. Finally, pure Fmoc-N-methyl-L-norleucine was obtained through appropriate purification and crystallization techniques.
Safety Information:
Fmoc-N-methyl-L-norleucine is less dangerous under normal operation. However, the following should be noted during handling and storage:
-Avoid contact with skin and eyes, wear protective gloves and goggles.
-Operate in a well-ventilated place to avoid inhaling dust or generating high dust concentration.
-Store in a dry, cool place, away from other chemicals and flammables.
-If accidentally ingested or inhaled, seek medical attention immediately and present information about this compound to your doctor.
Nature:
-Appearance: A white solid
-Molecular formula: C21H25NO4
-Molecular weight: 355.43g/mol
-Melting point: 108-112°C
-Storage conditions: Store in a low temperature, dry and ventilated place
Use:
Fmoc-N-methyl-L-norleucine is an important organic synthesis intermediate, which is widely used in the field of peptide synthesis. Its main uses include:
-Peptide synthesis: As a building block of amino acid fragments, it is used for the synthesis of polypeptide chains and research in the field of protein engineering.
-Drug development: research and development for the synthesis of peptide-related drugs and other biologically active molecules.
-Chemical biology: used to synthesize peptide probes and labels, used to study biological processes and the mechanism of cell signaling.
Preparation Method:
The preparation method of Fmoc-N-methyl-L-norleucine is mainly obtained by organic synthesis reaction, the specific steps include:
1. First, L-norleucine is reacted with a methylating agent to replace the hydrogen atom on the amino group with a methyl group.
2. Next, the obtained product is reacted with an Fmoc group compound to introduce an amino protecting group.
3. Finally, pure Fmoc-N-methyl-L-norleucine was obtained through appropriate purification and crystallization techniques.
Safety Information:
Fmoc-N-methyl-L-norleucine is less dangerous under normal operation. However, the following should be noted during handling and storage:
-Avoid contact with skin and eyes, wear protective gloves and goggles.
-Operate in a well-ventilated place to avoid inhaling dust or generating high dust concentration.
-Store in a dry, cool place, away from other chemicals and flammables.
-If accidentally ingested or inhaled, seek medical attention immediately and present information about this compound to your doctor.
Last Update：2024-04-09 21:01:54
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