N-Fmoc-L-alanine N-hydroxysuccinimide ester (Fmoc-Ala-OSu) is an important chemical reagent commonly used in the synthesis of peptide chains. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance is white or off-white solid.
-Stable at room temperature, but sensitive to humidity.
-Soluble in solution in dimethyl sulfoxide (DMSO) or dichloromethane (DCM).
-The chemical structure is Fmoc-protected L-alanine is esterified with hydroxysuccinimide.
Use:
- Fmoc-Ala-OSu alanine residues commonly used in the synthesis of polypeptide or protein sequences.
-As an amino acid protecting group, the amino group of the alanine residue can be protected during synthesis.
-Through the hydroxysuccinimide ester reaction, Fmoc-Ala-OSu can be chain extended with other amino acid residues.
Preparation Method:
-The preparation of Fmoc-Ala-OSu is mainly prepared by reacting Fmoc-L-alanine with hydroxysuccinimide ester under alkaline conditions.
Safety Information:
- Fmoc-Ala-OSu is a chemical reagent that needs to be operated in a laboratory environment.
-Follow relevant safety practices when handling, including wearing appropriate protective equipment, such as lab gloves and glasses.
-Do not inhale, swallow or contact with skin.
-Should be stored in a dry, low temperature, away from direct sunlight.