Fin
Fingolimod hydrochloride
CAS: 162359-56-0
Molecular Formula: C19H34ClNO2
Fin - Names and Identifiers
| Name | Fingolimod hydrochloride |
| Synonyms | Fin FTY720 Fingolimod HCl limod hydrochloride FTY720 HYDROCHLORIDE Fingolimod HCL(FTY720) fingolimod hydrochloride Fingolimod hydrochloride Fingolimod (FTY720) hydrochloride 2-(4-octylphenylethyl)-2-aminopropane-1,3-diol HCL 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol,HCl 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride 2-AMINO-2-[2-(4-OCTYLPHENYL)ETHYL]-1,3-PROPANEDIOL, HYDROCHLORIDE |
| CAS | 162359-56-0 |
| EINECS | 680-631-1 |
| InChI | InChI=1/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3 |
| InChIKey | SWZTYAVBMYWFGS-UHFFFAOYSA-N |
Fin - Physico-chemical Properties
| Molecular Formula | C19H34ClNO2 |
| Molar Mass | 343.93 |
| Density | 1.016g/cm3 |
| Melting Point | 102-107°C |
| Boling Point | 479.5°C at 760 mmHg |
| Flash Point | 243.8°C |
| Solubility | water: soluble10mg/mL, clear |
| Vapor Presure | 5.28E-10mmHg at 25°C |
| Appearance | White solid |
| Color | white to beige |
| Merck | 14,4083 |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Refractive Index | 1.531 |
| Use | A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. |
| In vitro study | S1P acts on K562 cells and inhibits NK cell lysis. Various concentrations of FTY720 reversed the inhibitory effect of S1P with an IC50 of 173 nM. In addition, incubation at 10 nM FTY720 alone did not have any effect on the expression of costimulatory molecules. By comparing the effect of S1P with the combined effect of S1P and FTY720, FTY720 can reverse the increase in HLA-I expression induced by S1P, while the cell percentage and MFI are also improved. Medium and high dose FTY720-P also enhanced TGF-β1 levels. The expression of TGF-β1 and Foxp3 mRNA was up-regulated in the high dose FTY720-P group. Effector (Teff) cell proliferation was inhibited in medium and high dose FTY720-P groups with a Treg/Teff cell ratio of 1:1. At a ratio of 1:1, Teff cells in the high dose FTY720 group were also inhibited. |
| In vivo study | FTY720 treatment using early disease model Ph |
Fin - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| WGK Germany | 3 |
| RTECS | TY3130000 |
| HS Code | 29221990 |
| Toxicity | LD50 orally in rats: 300-600 mg/kg (Troncoso) |
Fin - Reference
| Reference Show more | 1. [IF=7.561] Ye Min et al."A Novel Radioimmune 99mTc-Labeled Tracer for Imaging Sphingosine 1-Phosphate Receptor 1 in Tumor Xenografts: An In Vitro and In Vivo Study."Front Immunol. 2021 Aug;0:3346 |
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