FUCOSTEROL
FUCOSTEROL
CAS: 17605-67-3
Molecular Formula: C29H48O
FUCOSTEROL - Names and Identifiers
FUCOSTEROL - Physico-chemical Properties
| Molecular Formula | C29H48O |
| Molar Mass | 412.69 |
| Density | 0.98±0.1 g/cm3(Predicted) |
| Melting Point | 118-120°C |
| Boling Point | 220-230 °C |
| Specific Rotation(α) | D20 -38.4° (chloroform) |
| Solubility | Soluble in most organic solvents |
| Appearance | White powder |
| Color | White to Off-White |
| pKa | 15.03±0.70(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00037543 |
| In vitro study | Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes. Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC 50 values of 27.94 and 70.41 μg/ml, respectively.Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC 50 values of 185.4, 43.3, and 34.0 µg/ml, respectively. Cell Viability Assay Cell Line: 3T3-L1 adipocytes Concentration: 0 μM; 25 μM; 50 μM Incubation Time: 7 days Result: Inhibited PPARα and C/EBPα expression. |
| In vivo study | Fucosterol (oral adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses. |
FUCOSTEROL - Risk and Safety
| WGK Germany | 3 |
FUCOSTEROL - Reference
| Reference Show more | 1. [IF=7.514] Qin Guo et al."Action of phytosterols on thermally induced trans fatty acids in peanut oil."Food Chem. 2021 May;344:128637 2. [IF=6.475] Siya Wu et al."Ethanol extract of Sargarsum fusiforme alleviates HFD/STZ-induced hyperglycemia in association with modulation of gut microbiota and intestinal metabolites in type 2 diabetic mice."Food Res Int. 2021 Sep;147:110550 3. [IF=5.537] Yue Yang et al."Application of near-infrared spectroscopy and chemometrics for the rapid quality assessment of Sargassum fusiforme."Postharvest Biol Tec. 2021 Mar;173:111431 |
FUCOSTEROL - Reference Information
| biological activity | Fucosterol is a sterol that can be separated from algae, seaweed or diatoms. Fucosterol has a variety of biological activities, including antioxidant, anti-fat, lowering blood cholesterol, anti-diabetic and anti-cancer activities. Fucosterol by inhibiting the expression of PPARα and C/EBPα to regulate adipogenesis, it can be used for anti-obesity reagent development research. |
| target | Human Endogenous Metabolite |
| in vitro study | Fucosterol (0-50μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes. Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC 50 values of 27.94 and 70.41 μg/ml, respectively.Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC 50 values of 185.4, 43.3, and 34.0g/ml, respectively. Cell Viability Assay Cell Line: 3T3-L1 adipocytes Concentration: 0 μM; 25 μM; 50 μM Incubation Time: 7 days Result: Inhibited PPARα and C/EBPα expression. |
| Cell Line: | 3T3-L1 adipocytes |
| Concentration: | 0 μM; 25 μM; 50 μM |
| Incubation Time: | 7 days |
| Result: | Inhibited PPARα and C/EBPα expression. |
| in vivo study | Fucosterol (oral adminstratin; 30 mg/kg) causesa significant decrease in series glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses. |
Last Update：2024-04-09 21:01:54
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View History
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