FOSPENYTOIN
Fosphenytoin_Sodium
CAS: 92134-98-0
Molecular Formula: C16H16N2NaO6P
FOSPENYTOIN - Names and Identifiers
| Name | Fosphenytoin_Sodium |
| Synonyms | ACC-9653 FOSPENYTOIN Fosphenytoin sodium Fosphenytoin_Sodium FOSPHENYTOIN SODIUM FOSPHENYTOIN DISODIUM SALT Fosphenytoin Sodium (350 mg) disodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate 5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt 5,5-Diphenyl-3-[[[di(sodiooxy)phosphinyl]oxy]methyl]-1H-imidazole-2,4(3H,5H)-dione (sp-4-2)-5,5-diphenyl-3-((phosphonooxy)methyl)-2,4-imidazolidinedione disodium salt |
| CAS | 92134-98-0 |
| InChI | InChI=1/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2 |
FOSPENYTOIN - Physico-chemical Properties
| Molecular Formula | C16H16N2NaO6P |
| Molar Mass | 386.28 |
| Melting Point | 220° (softens) |
| Solubility | H2O: ≥15mg/mL |
| Appearance | powder |
| Color | white to tan |
| Storage Condition | Inert atmosphere,2-8°C |
| In vivo study | Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg). |
FOSPENYTOIN - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R45 - May cause cancer R61 - May cause harm to the unborn child R22 - Harmful if swallowed |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933290000 |
| Toxicity | LD50 in mice, rats (mg/kg): 234, 363 i.v. (Smith) |
FOSPENYTOIN - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.462 ml | 12.308 ml | 24.616 ml |
| 5 mM | 0.492 ml | 2.462 ml | 4.923 ml |
| 10 mM | 0.246 ml | 1.231 ml | 2.462 ml |
| 5 mM | 0.049 ml | 0.246 ml | 0.492 ml |
Last Update：2024-01-02 23:10:35
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