FMOC-BETA-HOPRO-OH
(S)-2-(1-fmoc-2-pyrrolidinyl)acetic acid
CAS: 193693-60-6
Molecular Formula: C21H21NO4
FMOC-BETA-HOPRO-OH - Names and Identifiers
| Name | (S)-2-(1-fmoc-2-pyrrolidinyl)acetic acid |
| Synonyms | Fmoc-β-HoPro-OH FMOC-BETA-HOPRO-OH FMOC-PRO-(C*CH2)OH FMOC-BETA-HOMOPRO-OH Fmoc-L-beta-homoproline FMOC-L-BETA-HOMOPROLINE Fmoc-L-beta3-homoproline (S)-2-(1-fmoc-2-pyrrolidinyl)acetic acid (S)-2-(1-FMOC-2-PYRROLIDINYL)ACETIC ACID N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-L-BETA-HOMOPROLINE (S)-N-(9-FLUORENYLMETHOXYCARBONYL)-PYRROLIDINE-2-ACETIC ACID {(2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidin-2-yl}acetic acid (S)-2-CARBOXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID 9H-FLUOREN-9-YLMETHYL ESTER |
| CAS | 193693-60-6 |
| InChI | InChI=1/C21H21NO4/c23-20(24)12-14-6-5-11-22(14)21(25)26-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-4,7-10,14,19H,5-6,11-13H2,(H,23,24)/t14-/m0/s1 |
| InChIKey | ZNIGOUDZWCDFFC-AWEZNQCLSA-N |
FMOC-BETA-HOPRO-OH - Physico-chemical Properties
| Molecular Formula | C21H21NO4 |
| Molar Mass | 351.4 |
| Density | 1.282±0.06 g/cm3(Predicted) |
| Melting Point | 175-177 °C |
| Boling Point | 562.1±23.0 °C(Predicted) |
| Flash Point | 293.7°C |
| Vapor Presure | 1.8E-13mmHg at 25°C |
| BRN | 7798553 |
| pKa | 4.56±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.615 |
FMOC-BETA-HOPRO-OH - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
FMOC-BETA-HOPRO-OH - Introduction
(S)-2-(1-fmoc-2-pyrolidinyl) acetic acid is an organic compound commonly used as a protecting group for synthetic peptides and proteins. The following is a description of the nature, use, preparation and safety information of (S)-2-(1-fmoc-2-pyrrolidinyl)acetic acid:
Nature:
1. Chemical formula: C38H39N3O6
2. Molecular Weight: 633.74g/mol
3. Appearance: white crystalline powder
4. Melting Point: 174-178 ° C
5. Solubility: Soluble in organic solvents (such as dimethyl sulfoxide and methanol), insoluble in water
Use:
1. Peptide synthesis protecting group:(S)-2-(1-fmoc-2-pyrrolidinyl)acetic acid can be used as a protecting group, through which amino acids are linked into polypeptide chains.
2. Chemical modification:(S)-2-(1-fmoc-2-pyrrolidinyl)acetic acid can be used to modify and change the properties of proteins, so as to explore their functions in the fields of biology and medicine.
Method:
The preparation of (S)-2-(1-fmoc-2-pyrolidinyl) acetic acid generally involves the following steps:
1. First, L-homoproline is converted into its protected ester form by synthetic chemical methods.
2. Then, on the basis of the protected Ester, The Fmoc protecting group is introduced into the L-hyperproline molecule by reacting with fluorosulfoxone (Fmoc-OSu).
3. Finally, The (S)-2-(1-fmoc-2-pyrolidinyl) acetic acid product was obtained through purification and crystallization processes.
Safety Information:
1. (S)-2-(1-fmoc-2-pyrolidinyl) acetic acid is a chemical that requires proper storage and handling.
2. In handling and use, should take appropriate personal protective measures, such as wearing gloves, goggles and protective clothing.
3. Avoid inhalation, ingestion and contact with skin and eyes.
4. Chemicals should be stored in closed containers, away from fire and high temperature.
5. Pay attention to a well-ventilated laboratory environment during use.
6. Detailed safety information and operating instructions should refer to the safety data sheet provided by the supplier.
Nature:
1. Chemical formula: C38H39N3O6
2. Molecular Weight: 633.74g/mol
3. Appearance: white crystalline powder
4. Melting Point: 174-178 ° C
5. Solubility: Soluble in organic solvents (such as dimethyl sulfoxide and methanol), insoluble in water
Use:
1. Peptide synthesis protecting group:(S)-2-(1-fmoc-2-pyrrolidinyl)acetic acid can be used as a protecting group, through which amino acids are linked into polypeptide chains.
2. Chemical modification:(S)-2-(1-fmoc-2-pyrrolidinyl)acetic acid can be used to modify and change the properties of proteins, so as to explore their functions in the fields of biology and medicine.
Method:
The preparation of (S)-2-(1-fmoc-2-pyrolidinyl) acetic acid generally involves the following steps:
1. First, L-homoproline is converted into its protected ester form by synthetic chemical methods.
2. Then, on the basis of the protected Ester, The Fmoc protecting group is introduced into the L-hyperproline molecule by reacting with fluorosulfoxone (Fmoc-OSu).
3. Finally, The (S)-2-(1-fmoc-2-pyrolidinyl) acetic acid product was obtained through purification and crystallization processes.
Safety Information:
1. (S)-2-(1-fmoc-2-pyrolidinyl) acetic acid is a chemical that requires proper storage and handling.
2. In handling and use, should take appropriate personal protective measures, such as wearing gloves, goggles and protective clothing.
3. Avoid inhalation, ingestion and contact with skin and eyes.
4. Chemicals should be stored in closed containers, away from fire and high temperature.
5. Pay attention to a well-ventilated laboratory environment during use.
6. Detailed safety information and operating instructions should refer to the safety data sheet provided by the supplier.
Last Update：2024-04-09 21:01:54
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