FK-506
TACROLIMUS
CAS: 109581-93-3
Molecular Formula: C44H69NO12.H2O
FK-506 - Names and Identifiers
| Name | TACROLIMUS |
| Synonyms | FK-506 TACROLIMUS Tacrolimus monohydrate |
| CAS | 109581-93-3 |
| InChIKey | NWJQLQGQZSIBAF-MLAUYUEBSA-N |
FK-506 - Physico-chemical Properties
| Molecular Formula | C44H69NO12.H2O |
| Molar Mass | 822.03 |
| Melting Point | 127-129° |
| Appearance | Morphological powder |
| Storage Condition | -20°C |
| Physical and Chemical Properties | Bioactive Tacrolimus monohydrate (FK506 monohydrate) are macrolide compounds that Tacrolimus monohydrate combine with FK506 binding protein (FKBP) to form a complex and inhibit calcineurin (calcineurin phosphatase), thereby inhibiting T lymphocyte signal transduction and IL-2 transcription. It has strong immunosuppressive properties. |
FK-506 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | KD4201200 |
| HS Code | 2934990002 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara) |
FK-506 - Reference
| Reference Show more | 1. [IF=4.932] Sihao Zheng et al."Combination of matrine and tacrolimus alleviates acute rejection in murine heart transplantation by inhibiting DCs maturation through ROS/ERK/NF-κB pathway."Int Immunopharmacol. 2021 Dec;101:108218 |
FK-506 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.217 ml | 6.083 ml | 12.165 ml |
| 5 mM | 0.243 ml | 1.217 ml | 2.433 ml |
| 10 mM | 0.122 ml | 0.608 ml | 1.217 ml |
| 5 mM | 0.024 ml | 0.122 ml | 0.243 ml |
Last Update：2024-01-02 23:10:35
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