Molecular Formula | C30H22N4O2 |
Molar Mass | 470.52 |
Density | 1.310±0.06 g/cm3(Predicted) |
Boling Point | 709.3±60.0 °C(Predicted) |
pKa | 5.10±0.20(Predicted) |
Storage Condition | -20℃ |
In vitro study | ETP-46464 almost completely inhibited ATR activity at 100nM. ETP-46464 inhibited the activity of PI3Kα,mTOR and DNA-PKcs proteins with IC50 values of 170,0.6 and 36 nM, respectively. ETP-46464 can promote the breakage of the replication fork stagnation. ETP-46464 results in massive DNA damage in replicating cells. 1 μm ETP-46464 inhibits the appearance of the G2 / M phase checkpoint induced by ionizing radiation and leads to the presence of micronuclei or completely broken nuclei in the cell. ETP-46464 is especially toxic to p53-deficient cells, which is exacerbated by conditions created by replication stress, such as cyclin E expression. ETP-46464 almost completely inhibited ATR activity at 100nM. ETP-46464 inhibited the activity of PI3Kα,mTOR and DNA-PKcs proteins with IC50 values of 170,0.6 and 36 nM, respectively. ETP-46464 can promote the breakage of the replication fork stagnation. ETP-46464 results in massive DNA damage in replicating cells. 1 μm ETP-46464 inhibits the appearance of the G2 / M phase checkpoint induced by ionizing radiation and leads to the presence of micronuclei or completely broken nuclei in the cell. ETP-46464 is especially toxic to p53-deficient cells, which is exacerbated by conditions created by replication stress, such as cyclin E expression. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.125 ml | 10.627 ml | 21.253 ml |
5 mM | 0.425 ml | 2.125 ml | 4.251 ml |
10 mM | 0.213 ml | 1.063 ml | 2.125 ml |
5 mM | 0.043 ml | 0.213 ml | 0.425 ml |