Dichlorophenol
2,5-Dichlorophenol
CAS: 583-78-8
Molecular Formula: C6H4Cl2O
Dichlorophenol - Names and Identifiers
| Name | 2,5-Dichlorophenol |
| Synonyms | 2,5-DCP Dichlorophenol DICHLOROPHENOL-2,5 2,5-dichloro-pheno 2,5-Dichlorophenol 2,5-DICHLOROPHENOL 2,5-dichloro-phenol 2,5-DICHLOROPHENOL PESTANAL 6-HYDROXY-1,4-DICHLOROBENZENE 2,5-DICHLORO-1-HYDROXY-BENZENE |
| CAS | 583-78-8 |
| EINECS | 209-520-4 |
| InChI | InChI=1/C6H4Cl2O/c7-4-1-2-5(8)6(9)3-4/h1-3,9H |
Dichlorophenol - Physico-chemical Properties
| Molecular Formula | C6H4Cl2O |
| Molar Mass | 163 |
| Density | 1.3446 (rough estimate) |
| Melting Point | 54-57 °C (lit.) |
| Boling Point | 211 °C (lit.) |
| Flash Point | 100 °C |
| Water Solubility | 3 g/L (20 ºC) |
| Solubility | 2000mg/l (experimental) |
| Appearance | Crystals |
| Color | White to light brown |
| BRN | 1907692 |
| pKa | 7.53±0.10(Predicted) |
| Storage Condition | 0-6°C |
| Refractive Index | 1.4430 (estimate) |
| Physical and Chemical Properties | Character: White needle-like crystal. There is a special odor. melting point 56~58 ℃ boiling point 211 ℃ solubility: slightly soluble in water, soluble in ethanol, ether, benzene |
| Use | Used as medicine, dye and other intermediates, herbicide dicamba intermediate, nitrogen fertilizer Synergist, leather fungicide |
Dichlorophenol - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R34 - Causes burns R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2020 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | SK8600000 |
| TSCA | Yes |
| HS Code | 29081000 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 580 mg/kg |
Dichlorophenol - Nature
Open Data Verified Data
White needle-like crystals with special odor. Boiling point of 211 deg C (101. 858kPa). The melting point was 56-58 °c. Micro-soluble in water, soluble in ethanol, ether, benzene.
Last Update：2025-06-10 22:55:16
Dichlorophenol - Preparation Method
Open Data Verified Data
- with 2,5-chloroaniline as raw material, sulfuric acid and sodium nitrite were added for diazotization, and the product was obtained by hydrolysis.
- with 1,2, 4-trichlorobenzene as raw materials, adding caustic soda and solvent at a certain temperature and pressure for hydrolysis reaction, 2,5-dichlorophenol sodium and 2,4-chlorophenol sodium, and then acidified by hydrochloric acid to obtain crude mixture. Then, 2,4-chlorophenol was separated by urea addition method to obtain 2,5-dichlorophenol product.
Last Update：2022-01-01 10:42:02
Dichlorophenol - Application
Open Data Verified Data
pesticide intermediates, mainly used in the manufacture of herbicide wheat straw Dan and DP fungicide.
Last Update：2025-08-19 16:24:40
Dichlorophenol - Safety
Open Data Verified Data
- toxic. Production equipment should be closed, the operation site should be well ventilated, the operator should wear protective equipment.
- with fiber packaging barrel, lined with polyvinyl chloride packaging bag, each net weight 40kg, stored in a cool, dry warehouse, to prevent sun exposure.
Last Update：2025-06-10 22:55:16
Dichlorophenol - Reference Information
| LogP | 3.06 at 20℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| uses | used as intermediates in medicine, dyes, herbicide dicamba intermediate, nitrogen fertilizer synergist, leather mildew inhibitor, etc. 2, 5-dichlorophenol is an intermediate of herbicide dicamba, and can also be used to produce nitrogen fertilizer synergist. used as an intermediate in organic synthesis, mainly used in the manufacture of herbicide wheatgrass Dan and DP antifungal agent, nitrogen fertilizer synergist. |
| production method | 1.2, 5-dichloroaniline is used as raw material, sulfuric acid and sodium nitrite are added for diazotization, and the finished product is obtained by hydrolysis. 2. Using 1,2, 4-trichlorobenzene as raw material, adding caustic soda and solvent to carry out hydrolysis reaction at a certain temperature and pressure to obtain sodium 2, 5-dichlorophenol and sodium 2, 4-dichlorophenol, and then acidified by hydrochloric acid to obtain a crude mixture. Then, 2, 4-dichlorophenol was separated by urea addition method to obtain the finished product of 2, 5-dichlorophenol. The preparation method is to diazotize 2, 5-dichloroaniline first, and then hydrolyze to prepare 2, 5-dichlorophenol. 2, 5-dichloroaniline is first mixed with sulfuric acid in the reactor, sodium nitrite solution is added under cooling and stirring, and then stirring is continued for 1h. After the diazotization reaction is completed, filtration is carried out, and the filtrate is further added with water and heated to hydrolyze to obtain the product. You can also put 1,2, 4-trichlorobenzene in the reaction pot, add chlorosulfonic acid dropwise at 60°C, after the dropwise addition, the material is added to water to separate 2,4, 5-trichlorobenzenesulfonic acid, Add alkali solution to heat the reaction, and steam distillation to obtain 2, 5-dichlorophenol. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 580 mg/kg; Oral-mouse LD50: 946 mg/kg |
| flammability hazard characteristics | open flame is combustible; heated to release toxic chloride gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | carbon dioxide, sand, foam, dry powder |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 19:05:09
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