DOTA-NHS-ester
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester
CAS: 170908-81-3
Molecular Formula: C20H31N5O10
DOTA-NHS-ester - Names and Identifiers
DOTA-NHS-ester - Physico-chemical Properties
| Molecular Formula | C20H31N5O10 |
| Molar Mass | 501.48764 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Boling Point | 743.7±70.0 °C(Predicted) |
| pKa | 2.46±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Bioactive DOTA-NHS-ester are cross-linking agents (linker) for affibody molecules and can be used for positron emission tomography (PET), single photon emission computed tomography (SPECT) and CT scanning in small animals. DOTA-NHS-ester can be used to label radiation research agents or imaging probes to detect tumors. |
DOTA-NHS-ester - Upstream Downstream Industry
DOTA-NHS-ester - Uses and synthesis methods
in vitro studies
DOTA-NHS-ester can be used to modify human serum albumin (HSA) to produce DOTA-HSA. And DOTA-HSA is furtherly modified by Sulfo-SMCC (HY-D0975) to obtain DOTA-HSA-SMCC. DOTA-HSA-SMCC is conjugated to ZHER2:342 and the final product is DOTA-HSA-Z HER2 :342 . In a cell uptake assay, DOTA-HSA-Z HER2 :342 is labeled by 64 Cu, 64 Cu-DOTA-HSA-Z HER2 :342 (0.5-2 hours) slowly accumulates in the SKOV3 cells and reaches 0.71% of the applied activity at 0.5 h and the uptake increased to 1.58% at 2 h.
In vivo studies
In a microPET images of a mouse bearing SKOV3 tumor, 64 Cu-DOTA-HSA-Z HER2 :342 is injected to the mouse tail. microPET images of a mouse bearing SKOV3 tumor at 1, 4, 24 and 48 h after tail vein injection.The SKOV3 tumor is visible with a low tumor-to-background contrast at 1 h post-injection (p. I .), but with a very good tumor-to-background contrast at 4 and 24 h p. I .Quantification analysis reveals that the SKOV3 tumor uptake values increases with time and are found to be 5.63%, 9.98%, 14.34% and 14.12% ID/g at 1, 4, 24, and 48 h, respectively.
Last Update：2024-04-10 22:29:15
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Product Name: 2,2',2''-(10-(2-((2,5-Dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triaceticacid Request for quotationCAS: 170908-81-3
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Product Name: 2,2',2''-(10-(2-((2,5-Dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triaceticacid Request for quotationCAS: 170908-81-3
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Product Name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester Visit Supplier Webpage Request for quotation
CAS: 170908-81-3
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View History
Raw Materials for DOTA-NHS-ester
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-diMethylethyl) ethyl ester
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-diMethylethyl) phenylMethyl ester
DOTA-mono-NHS-tris(t-Bu ester)(B-270)
Cyclen
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-diMethylethyl) phenylMethyl ester
DOTA-mono-NHS-tris(t-Bu ester)(B-270)
Cyclen