DL-Homocysteine
DL-Homocysteine
CAS: 454-29-5
Molecular Formula: C4H9NO2S
DL-Homocysteine - Names and Identifiers
| Name | DL-Homocysteine |
| Synonyms | homocysteine DL-HoMocystein D-homocysteine DL-Homocysteine (+-)-homocysteine HOMOCYSTEINE, DL-(P) dl-2-amino-4-mercaptobutyricacid (2R)-2-ammonio-4-mercaptobutanoate Butyric acid, 2-amino-4-mercapto-, DL- (9CI) DL-Homocysteine 2-Amino-4-mercaptobuyric acid DL-Homocysteine,2-Amino-4-mercaptobutyric acid |
| CAS | 454-29-5 |
| EINECS | 207-222-9 |
| InChI | InChI=1/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m1/s1 |
| InChIKey | FFFHZYDWPBMWHY-UHFFFAOYSA-N |
DL-Homocysteine - Physico-chemical Properties
| Molecular Formula | C4H9NO2S |
| Molar Mass | 135.18 |
| Density | 1.149 (estimate) |
| Melting Point | 232-233°C(lit.) |
| Boling Point | 299.7±35.0 °C(Predicted) |
| Flash Point | >230°F |
| Solubility | H2O: soluble |
| Vapor Presure | 0.000278mmHg at 25°C |
| Appearance | White powder |
| Color | White to Off-White |
| Merck | 14,4734 |
| BRN | 1721683 |
| pKa | 2.22, 8.87, 10.86(at 25℃) |
| Storage Condition | -20°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5480 (estimate) |
| MDL | MFCD00004898 |
| In vitro study | DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC 50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC 50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC 50 value of 8.046 (5.804-11.154) mM. |
| In vivo study | DL-Homocysteine (1.3 mmol/kg, i.p.) increases KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 and 11.4 ± 1.72 in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 in rat hippocampus. |
DL-Homocysteine - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | MT0175000 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29309090 |
| Toxicity | LD50 intraperitoneal in mouse: 500mg/kg |
DL-Homocysteine - Reference
| Reference Show more | 1. [IF=1.448] Xiaoqin Zhong et al."Scutellarin‑treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells."Exp Ther Med. 2019 Jul;18(1):33-40 |
DL-Homocysteine - Reference Information
| use | DL-homocysteine is an allosteric antagonist of dopamine d2 receptor. L-homocysteine (H591950) is mainly naturally occurring and can be recycled to methionine or converted to cysteine. |
| Biological activity | DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. DL-Homocysteine can inhibit the activities of KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II. |
| Target | Value |
Last Update：2024-04-09 21:11:58
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